Table 1.
Histological subtype, merlin status, and IC50 values for each cell line
| Cell line | Histological subtype | Merlin status | IC50 of BI 853520 (μM) |
|---|---|---|---|
| Met5a | Immortalized mesothelial cell | − | 9 |
| Meso49 | Epithelioid MPM | − | 5.5 |
| Meso53 | Biphasic MPM | + | 5.5 |
| SPC111 | Biphasic MPM | − | 5.6 |
| P31 | Epithelioid MPM | − | 5.9 |
| VMC20 | Epithelioid MPM | − | 5.9 |
| VMC23 | Epithelioid MPM | − | 5.8 |
| M38K | Biphasic MPM | + | 6.6 |
| VMC40 | Biphasic MPM | − | 7.5 |
| Meso62 | Sarcomatoid MPM | − | 8.8 |
| SPC212 | Biphasic MPM | + | 10.2 |
| VMC6 | Epithelioid MPM | − | 11.5 |
| VMC12 | Epithelioid MPM | + | 11.3 |