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. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: Cancer Lett. 2018 Nov 1;442:91–103. doi: 10.1016/j.canlet.2018.10.020

Table 3. The effect of IPI-549 on the resistance fold of MDR ABCG2-overexpressing cells.

Drug S1 IC50 ± SD (μM) RFa S1-M1–80 IC50 ± SD (μM) RFa
Mitoxantrone 0.0089 ± 0.001 1.0 9.1993 ± 0.027 1032.8
+IPI-549 2.5 μM 0.0073 ± 0.015 1.0 6.1125 ± 0.002 686.2
+IPI-549 5 μM 0.0084 ± 0.075 1.0 5.0815 ± 0.029 570.4
+Nilotinib 5 μM 0.0073 ± 0.007 1.0 0.0830 ± 0.005 9.32*

IC50 values are represented as a mean ± SD of three independent experiments performed in triplicate.

a

Resistance fold (RF) was the IC50 values of the S1-M1–80 cells with and without IPI- 549 or verapamil divided by the IC50 value of S1 cells without reversing agents.

*

P < 0.01 versus the control group.