Table 3. Stratified analysis of TIMP4 polymorphisms with the gender and clinical phenotypes of steroid-induced ONFH.
Under the genotypes, rs3817004 showed a significant association with steroid-induced ONFH in gender, that is, in the heterozygous (GA) carriers of rs3817004 (G/A), the proportion (40.1%) of male was significantly increased compared with the proportion (30.1%) of female (p = 0.016). Bold values are statistically different (p ≤ 0.05).
| SNP-ID | Gender n (%)a | Hip lesionsn (%)a | Clinical stagesn (%)a | |||||
|---|---|---|---|---|---|---|---|---|
| Genotype | Male | Female | Unilateral | Bilateral | II | III | IV | |
| rs99365 | TT | 4(2.3) | 7(6,2) | 1(1.2) | 10(5) | 2(3.2) | 4(3.2) | 5(5.2) |
| TC | 63(36.6) | 38(33.6) | 25(30.1) | 76(37.6) | 16(25.4) | 55(43.7) | 30(31.2) | |
| CC | 105(61) | 68(60.2) | 57(68.7) | 116(57.4) | 45(71.4) | 67(53.2) | 61(63.5) | |
| P | 0.243 | 0.117 | 0.097 | |||||
| rs17035945 | TT | 3(1.7) | 3(2.7) | 1(1.2) | 5(2.5) | 0(0) | 2(1.6) | 4(4.2) |
| TC | 41(23.8) | 26(23) | 17(20.7) | 50(24.6) | 19(29.7) | 22(17.5) | 26(27.4) | |
| CC | 128(74.4) | 84(74.3) | 64(78) | 148(72.9) | 45(70.3) | 102(81) | 65(68.4) | |
| P | 0.866 | 0.602 | 0.077 | |||||
| rs308952 | AA | 4(2.3) | 9(8) | 1(1.2) | 12(5.9) | 2(3.1) | 5(4) | 6(6.2) |
| AG | 64(37) | 35(3.1) | 25(30.1) | 74(36.6) | 17(26.6) | 53(42.4) | 29(30.2) | |
| GG | 105(60.7) | 68(60.7) | 57(68.7) | 116(57.4) | 45(70.3) | 67(53.6) | 61(63.5) | |
| P | 0.063 | 0.089 | 0.134 | |||||
| rs3817004 | GG | 3(1.7) | 9(8) | 1(1.2) | 11(5.4) | 2(3.1) | 5(4) | 5(5.2) |
| GA | 69(40.1) | 34(30.1) | 26(31.3) | 77(37.9) | 18(28.1) | 54(42.9) | 31(32.3) | |
| AA | 101(58.7) | 70(61.9) | 56(67.5) | 115(56.7) | 44(68.8) | 67(53.2) | 60(62.5) | |
| P | 0.016 | 0.113 | 0.245 | |||||
| rs28897670 | GG | 1(0.6) | 2(1.8) | 0(0) | 3(1.5) | 0(0) | 1(0.8) | 2(2.1) |
| GA | 31(17.9) | 17(15) | 13(15.7) | 35(17.2) | 14(21.9) | 14(11.1) | 20(20.8) | |
| AA | 141(81.5) | 94(83.2) | 70(84.3) | 165(81.3) | 50(78.1) | 111(88.1) | 74(77.1) | |
| P | 0.526 | 0.501 | 0.134 | |||||
| rs2279750 | CC | 5(2.9) | 8(7.1) | 1(1.2) | 12(5.9) | 3(4.8) | 6(4.8) | 4(4.2) |
| CA | 62(36) | 36(31.9) | 26(31.3) | 72(35.6) | 16(25.4) | 52(41.3) | 30(31.2) | |
| AA | 105(61) | 69(61.1) | 56(67.5) | 118(58.4) | 44(69.8) | 68(54) | 62(64.6) | |
| P | 0.229 | 0.135 | 0.234 | |||||
| rs3755724 | CC | 27(15.6) | 21(18.6) | 11(13.3) | 37(18.2) | 11(17.2) | 20(15.9) | 17(17.7) |
| CT | 88(50.9) | 47(41.6) | 36(43.4) | 99(48.8) | 26(40.6) | 64(50.8) | 45(46.9) | |
| TT | 58(33.5) | 45(39.8) | 36(43.4) | 67(33) | 27(42.2) | 42(33.3) | 34(35.4) | |
| P | 0.307 | 0.224 | 0.738 | |||||
Notes.
a
X2 text.