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. 2019 Jan 24;7:e6270. doi: 10.7717/peerj.6270

Table 4. Genotypic model analysis of relationship between SNPs and steroid-induced ONFH risk.

For genotypic model analysis, five different genetic models were used to more deeply analyze the associations between the SNPs and the risk of steroid-induced ONFH. Bold values are statistically different (p ≤ 0.05).

SNP Model Genotype Group=control Group=case Without adjustment With adjustmenta
OR(95% CI) pb-value OR(95% CI) pb-value
rs99365 C/C 162(52.8%) 173(60.7%) 1.00 1.00
Codominant C/T 122(39.7%) 101(35.4%) 0.78(0.55–1.09) 0.054 0.78(0.55–1.11) 0.1
T/T 23(7.5%) 11(3.9%) 0.45(0.21–0.95) 0.48(0.22–1.07)
Dominant C/C 162(52.8%) 173(60.7%) 1.00 0.052 1.00 0.077
C∕T − T∕T 145(47.2%) 112(39.3%) 0.72(0.52–1.00) 0.73(0.52–1.03)
Recessive C∕C − C∕T 284(92.5%) 274(96.1%) 1.00 0.055 1.00 0.11
T/T 23(7.5%) 11(3.9%) 0.50(0.24–1.04) 0.53(0.25–1.16)
Log-additive 0.73(0.55–0.95) 0.02 0.74(0.56–0.99) 0.038
rs308952 G/G 162(52.8%) 173(60.7%) 1.00 1.00
Codominant A/G 122(39.7%) 99(34.7%) 0.76 (0.54–1.07) 0.093 0.77(0.54–1.09) 0.13
A/A 23(7.5%) 13 (4.6%) 0.53 (0.26–1.08) 0.53(0.25–1.14)
Dominant G/G 162 (52.8%) 173 (60.7%) 1.00 0.052 1.00 0.071
A∕G − A∕A 145 (47.2%) 112 (39.3%) 0.72 (0.52–1.00) 0.73(0.52–1.03)
Recessive G∕G − A∕G 284 (92.5%) 272 (95.4%) 1.00 0.13 1.00 0.16
A/A 23 (7.5%) 13 (4.6%) 0.59 (0.29–1.19) 0.59(0.28–1.25)
Log-additive 0.74(0.57–0.97) 0.03 0.75(0.56–0.99) 0.044
rs3817004 A/A 163 (52.8%) 171 (59.8%) 1.00 1.00
Codominant G/A 123 (39.8%) 103 (36%) 0.80(0.57–1.12) 0.1 0.79(0.55–1.13) 0.11
G/G 23 (7.4%) 12 (4.2%) 0.50(0.24–1.03) 0.48(0.22–1.05)
Dominant A/A 163 (52.8%) 171 (59.8%) 1.00 0.084 1.00 0.088
G∕A − G∕G 146 (47.2%) 115 (40.2%) 0.75(0.54–1.04) 0.74(0.53–1.05)
Recessive A∕A − G∕A 286 (92.6%) 274 (95.8%) 1.00 0.089 1.00 0.096
G/G 23 (7.4%) 12 (4.2%) 0.54(0.27–1.12) 0.53(0.25–1.14)
Log-additive 0.75(0.58–0.99) 0.038 0.75(0.56–0.99) 0.042
rs2279750 A/A 159 (51.6%) 174 (61%) 1.00 1.00
Codominant C/A 126 (40.9%) 98 (34.4%) 0.71(0.51–1.00) 0.047 0.73(0.51–1.05) 0.089
C/C 23 (7.5%) 13 (4.6%) 0.52(0.25–1.05) 0.53(0.25–1.12)
Dominant A/A 159 (51.6%) 174 (61%) 1.00 0.021 1.00 0.042
C∕A − C∕C 149 (48.4%) 111 (39%) 0.68 (0.49–0.94) 0.70(0.50–0.99)
Recessive A∕A − C∕A 285 (92.5%) 272 (95.4%) 1.00 0.14 1.00 0.16
C/C 23 (7.5%) 13 (4.6%) 0.59(0.29–1.19) 0.59(0.28–1.25)
Log-additive 0.71(0.55–0.93) 0.014 0.73(0.55–0.97) 0.028
rs3755724 T/T 85 (27.7%) 103 (36%) 1.00 1.00
Codominant T/C 159 (51.8%) 135 (47.2%) 0.70(0.49–1.01) 0.083 0.77(0.52–1.13) 0.29
C/C 63 (20.5%) 48 (16.8%) 0.63(0.39–1.01) 0.71(0.43–1.17)
Dominant T/T 85 (27.7%) 103 (36%) 1.00 0.029 1.00 0.12
T∕C − C∕C 222 (72.3%) 183 (64%) 0.68(0.48–0.96) 0.75(0.52–1.08)
Recessive T∕T − T∕C 244 (79.5%) 238 (83.2%) 1.00 0.24 1.00 0.43
C/C 63 (20.5%) 48 (16.8%) 0.78(0.52–1.18) 0.84(0.54–1.30)
Log-additive 0.78(0.62–0.98) 0.035 0.83(0.65–1.06) 0.14

Notes.

a

p value was adjusted by age.