Table 4. Genotypic model analysis of relationship between SNPs and steroid-induced ONFH risk.
SNP | Model | Genotype | Group=control | Group=case | Without adjustment | With adjustmenta | ||
---|---|---|---|---|---|---|---|---|
OR(95% CI) | pb-value | OR(95% CI) | pb-value | |||||
rs99365 | C/C | 162(52.8%) | 173(60.7%) | 1.00 | 1.00 | |||
Codominant | C/T | 122(39.7%) | 101(35.4%) | 0.78(0.55–1.09) | 0.054 | 0.78(0.55–1.11) | 0.1 | |
T/T | 23(7.5%) | 11(3.9%) | 0.45(0.21–0.95) | 0.48(0.22–1.07) | ||||
Dominant | C/C | 162(52.8%) | 173(60.7%) | 1.00 | 0.052 | 1.00 | 0.077 | |
C∕T − T∕T | 145(47.2%) | 112(39.3%) | 0.72(0.52–1.00) | 0.73(0.52–1.03) | ||||
Recessive | C∕C − C∕T | 284(92.5%) | 274(96.1%) | 1.00 | 0.055 | 1.00 | 0.11 | |
T/T | 23(7.5%) | 11(3.9%) | 0.50(0.24–1.04) | 0.53(0.25–1.16) | ||||
Log-additive | — | — | — | 0.73(0.55–0.95) | 0.02 | 0.74(0.56–0.99) | 0.038 | |
rs308952 | G/G | 162(52.8%) | 173(60.7%) | 1.00 | 1.00 | |||
Codominant | A/G | 122(39.7%) | 99(34.7%) | 0.76 (0.54–1.07) | 0.093 | 0.77(0.54–1.09) | 0.13 | |
A/A | 23(7.5%) | 13 (4.6%) | 0.53 (0.26–1.08) | 0.53(0.25–1.14) | ||||
Dominant | G/G | 162 (52.8%) | 173 (60.7%) | 1.00 | 0.052 | 1.00 | 0.071 | |
A∕G − A∕A | 145 (47.2%) | 112 (39.3%) | 0.72 (0.52–1.00) | 0.73(0.52–1.03) | ||||
Recessive | G∕G − A∕G | 284 (92.5%) | 272 (95.4%) | 1.00 | 0.13 | 1.00 | 0.16 | |
A/A | 23 (7.5%) | 13 (4.6%) | 0.59 (0.29–1.19) | 0.59(0.28–1.25) | ||||
Log-additive | — | — | — | 0.74(0.57–0.97) | 0.03 | 0.75(0.56–0.99) | 0.044 | |
rs3817004 | A/A | 163 (52.8%) | 171 (59.8%) | 1.00 | 1.00 | |||
Codominant | G/A | 123 (39.8%) | 103 (36%) | 0.80(0.57–1.12) | 0.1 | 0.79(0.55–1.13) | 0.11 | |
G/G | 23 (7.4%) | 12 (4.2%) | 0.50(0.24–1.03) | 0.48(0.22–1.05) | ||||
Dominant | A/A | 163 (52.8%) | 171 (59.8%) | 1.00 | 0.084 | 1.00 | 0.088 | |
G∕A − G∕G | 146 (47.2%) | 115 (40.2%) | 0.75(0.54–1.04) | 0.74(0.53–1.05) | ||||
Recessive | A∕A − G∕A | 286 (92.6%) | 274 (95.8%) | 1.00 | 0.089 | 1.00 | 0.096 | |
G/G | 23 (7.4%) | 12 (4.2%) | 0.54(0.27–1.12) | 0.53(0.25–1.14) | ||||
Log-additive | — | — | — | 0.75(0.58–0.99) | 0.038 | 0.75(0.56–0.99) | 0.042 | |
rs2279750 | A/A | 159 (51.6%) | 174 (61%) | 1.00 | 1.00 | |||
Codominant | C/A | 126 (40.9%) | 98 (34.4%) | 0.71(0.51–1.00) | 0.047 | 0.73(0.51–1.05) | 0.089 | |
C/C | 23 (7.5%) | 13 (4.6%) | 0.52(0.25–1.05) | 0.53(0.25–1.12) | ||||
Dominant | A/A | 159 (51.6%) | 174 (61%) | 1.00 | 0.021 | 1.00 | 0.042 | |
C∕A − C∕C | 149 (48.4%) | 111 (39%) | 0.68 (0.49–0.94) | 0.70(0.50–0.99) | ||||
Recessive | A∕A − C∕A | 285 (92.5%) | 272 (95.4%) | 1.00 | 0.14 | 1.00 | 0.16 | |
C/C | 23 (7.5%) | 13 (4.6%) | 0.59(0.29–1.19) | 0.59(0.28–1.25) | ||||
Log-additive | — | — | — | 0.71(0.55–0.93) | 0.014 | 0.73(0.55–0.97) | 0.028 | |
rs3755724 | T/T | 85 (27.7%) | 103 (36%) | 1.00 | 1.00 | |||
Codominant | T/C | 159 (51.8%) | 135 (47.2%) | 0.70(0.49–1.01) | 0.083 | 0.77(0.52–1.13) | 0.29 | |
C/C | 63 (20.5%) | 48 (16.8%) | 0.63(0.39–1.01) | 0.71(0.43–1.17) | ||||
Dominant | T/T | 85 (27.7%) | 103 (36%) | 1.00 | 0.029 | 1.00 | 0.12 | |
T∕C − C∕C | 222 (72.3%) | 183 (64%) | 0.68(0.48–0.96) | 0.75(0.52–1.08) | ||||
Recessive | T∕T − T∕C | 244 (79.5%) | 238 (83.2%) | 1.00 | 0.24 | 1.00 | 0.43 | |
C/C | 63 (20.5%) | 48 (16.8%) | 0.78(0.52–1.18) | 0.84(0.54–1.30) | ||||
Log-additive | — | — | — | 0.78(0.62–0.98) | 0.035 | 0.83(0.65–1.06) | 0.14 |
Notes.
p value was adjusted by age.