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. Author manuscript; available in PMC: 2020 Jan 1.
Published in final edited form as: Atherosclerosis. 2018 Nov 27;280:183–191. doi: 10.1016/j.atherosclerosis.2018.11.031

Fig. 1. Atherosclerosis-associated and normal aorta DMRs: genome-wide associations.

Fig. 1.

(A) Pie charts showing that athero DMRs were mostly athero hypermeth DMRs. (B) Athero hypermeth DMRs, but not athero hypometh DMRs, were greatly enriched in aorta enhancer chromatin. (C) The distribution of athero DMRs among gene regions. (D) Bar graphs showing the strong overlap of athero DMRs with aorta DMRs of the opposite directionality (athero hypermeth with aorta hypometh and vice versa) and athero DMRs overlap with monocyte DMRs of the same directionality. (E-G), parallel to (A-C) but for tissue-specific aorta DMRs (control aorta vs. heart/skeletal muscle/lung/adipose/monocytes), which indicated that the athero hypermeth DMRs are most similar to the aorta hypometh DMRs and vice versa. Enh, enhancer-type chromatin.