Table 1.

Summary of studies examining depression-related behavior in rodent models of TBI. TBI was delivered to anaesthetised adult animals, unless otherwise stated. FST – Forced Swim Test, SPT –Sucrose preference test, TST – Tail Suspension Test, NSFT – Novelty Suppressed Feeding Test, CCI – Controlled Cortical Impact, FPI - Fluid Percussion Injury, GSK-3 – Glycogen synthase kinase 3, LiCl – Lithium chloride, DHEAS – Dehydroepiandrosterone, TSG-6 – Tumor necrosis factor stimulated gene 6.

Model	Citation	Species	Severity	Frequency	Test	Depression phenotype
Weight-drop	Milman, 2005	Mouse	Mild	Single	FST	Depression-like phenotype in TBI mice
	Shapira et al., 2007	Mouse	Mild	Single	FST	Depression-like phenotype in TBI, reversed by LiCl, GSK-3 inhibitor
	Tweedie, 2007	Mouse	Mild	Single	FST	Depression-like phenotype in TBI mice
	Milman, 2008	Mouse	Mild	Single	FST	Depression-like phenotype in TBI, improvement at 90 days with DHEAS treatment
	Lesniak, 2017	Mouse	Mild	Single	TST	Increased depression-like behaviour following TBI in LA mice
	Kosari-Nasab, 2018	Mouse	Mild	Single	FST, SPT	Depression-like phenotype in TBI mice
	Nichols, 2016	Mouse	Mild	Repeated	FST	No phenotype in TBI mice
	Liu, 2017	Mouse	Mild	Repeated	FST	No phenotype in TBI mice
	Schwarzbold, 2010	Mouse	Variable	Single	FST	No phenotype in TBI mice
	Corrigan, 2017	Rat	Mild	Repeated	FST	Depression-like phenotype in TBI rats
	Tan et al., 2015	Rat	Not classified	Single	FST, SPT	Depression-like phenotype in TBI rats, reduced by amantadine
CCI	Yang, 2015	Mouse	Mild	Repeated	FST	No phenotype in TBI mice
	Wang, 2011	Mouse	Moderate	Single	FST	No phenotype in TBI mice
	Washington et al., 2012	Mouse	Variable	Single	FST	Depression-like phenotype in TBI mice
	Tucker et al., 2017	Mouse	Variable	Single	SPT, FST	No phenotype in TBI mice
	Watanabe et al., 2013	Mouse	Not classified	Single	FST, NSFT	Depression-like phenotype in TBI mice, improved by TSG-6 (anti-inflammatory) treatment
	Petraglia et al., 2014	Mouse (conscious)	Not classified	Repeated	FST,TST	Depression-like phenotype in TBI mice
	Klemenhagen et al., 2013	Mouse	Not classified	Repeated	TST, SPT	Depression-like phenotype in TBI mice
	Cope et al., 2011	Rat	Not classified	Single	SPT	Depression-like phenotype in TBI rats, improved by zinc supplementation
	Cope, 2012	Rat	Not classified	Single	SPT	Depression-like phenotype in TBI rats
	Darkazalli et al., 2016	Rat	Not classified	Single	SPT	Depression-like phenotype in TBI rats, reversed with stem cell treatment
FPI	Shultz et al., 2012a	Rat	Mild	Single	FST	No phenotype in TBI rats
	Shultz et al., 2012b	Rat	Mild	Repeated	FST	Depression-like phenotype in TBI rats
	Webster et al., 2015	Rat	Mild	Repeated	FST	No phenotype in TBI rats
	Mychasiuk et al., 2014a, 2014b	Rat (juvenile)	Mild	Single	FST	Depression-like phenotype in TBI rats
	Jones et al., 2008	Rat	Moderate	Single	FST, SPT	No phenotype in TBI rats
	Rowe, 2016	Rat (varying ages)	Moderate	Single	FST	No phenotype in TBI rats
Blast injury	Reiner, 2015	Mouse	Mild	Single	TST	Depression-like phenotype in TBI mice, reversed by SMM-189 - CB2 receptor inverse agonist
	Heldt, 2014	Mouse	Variable	Single	TST	Depression-like phenotype in 60psi injured vs 30psi injured rats