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. Author manuscript; available in PMC: 2020 Mar 1.
Published in final edited form as: Neurobiol Dis. 2018 Jul 27;123:27–41. doi: 10.1016/j.nbd.2018.07.018

Table 3.

Summary of studies examining cognition in rodent models of TBI. This field has been studied extensively, so by necessity our table omits several published works from 2014 and for published work prior, readers are directed to detailed reviews (Paterno et al., 2017; Tucker et al., 2018). MWM- Morris water maze, RAM- Radial 8-arm maze.

Model Citation Species Severity Frequency Test Cognitive behaviour changes
Weight drop (Mychasiuk et al., 2014) rat mild single MWM, Novel context mismatch Reduced cognitive function in TBI
Mychasiuk et al., 2015b rat mild single Novel context mismatch Short term memory reduced in both male and female
(Hou et al., 2017) rat Mild/moderate single MWM Acute and chronic cognitive decline in TBI
Closed skull (Broussard et al., 2018) mice mild Single/repeated MWM Acute cognitive decline in repeated TBI
(Wright et al., 2017a) rat mild Single/repeated Novel context mismatch Impairment in working memory in both single and repeated injury
(Bajwa et al., 2016) mice mild Single/repeated MWM Decline in spatial learning in acute and chronic stages in TBI
Blast injury (Perez-Polo et al., 2015) rat mild single MWM Decline in reference memory 5days post TBI
CCI (Semple et al., 2017a) mice severe single Y maze Reduced spatial recognition in male TBI
(Semple et al., 2017b) mice Moderate/severe Single MWM Reduced cognition in TBI
(Bajwa et al., 2016) mice moderate Single MWM Severe cognitive decline
(Sebastian et al., 2013b) rat Moderate single RAM Reduced short term working memory in TBI, no change in long term reference memory
(Song et al., 2016b) mice mild single RAM Reduced working memory in TBI
FPI (Shultz et al., 2015) rat severe single MWM Reduced cognition 12weeks post TBI
(Johnstone et al., 2015) rat moderate single MWM Cognitive decline in TBI
(Webster et al., 2015) rat mild repeated MWM Chronic reduced cognition in TBI
(Wright et al., 2016a) rat mild repeated MWM Reduced cognition in TBI
(Shultz et al., 2014) mice moderate Single Y maze Reduced spatial recognition in TBI