Table 3.
Summary of studies examining cognition in rodent models of TBI. This field has been studied extensively, so by necessity our table omits several published works from 2014 and for published work prior, readers are directed to detailed reviews (Paterno et al., 2017; Tucker et al., 2018). MWM- Morris water maze, RAM- Radial 8-arm maze.
Model | Citation | Species | Severity | Frequency | Test | Cognitive behaviour changes |
---|---|---|---|---|---|---|
Weight drop | (Mychasiuk et al., 2014) | rat | mild | single | MWM, Novel context mismatch | Reduced cognitive function in TBI |
Mychasiuk et al., 2015b | rat | mild | single | Novel context mismatch | Short term memory reduced in both male and female | |
(Hou et al., 2017) | rat | Mild/moderate | single | MWM | Acute and chronic cognitive decline in TBI | |
Closed skull | (Broussard et al., 2018) | mice | mild | Single/repeated | MWM | Acute cognitive decline in repeated TBI |
(Wright et al., 2017a) | rat | mild | Single/repeated | Novel context mismatch | Impairment in working memory in both single and repeated injury | |
(Bajwa et al., 2016) | mice | mild | Single/repeated | MWM | Decline in spatial learning in acute and chronic stages in TBI | |
Blast injury | (Perez-Polo et al., 2015) | rat | mild | single | MWM | Decline in reference memory 5days post TBI |
CCI | (Semple et al., 2017a) | mice | severe | single | Y maze | Reduced spatial recognition in male TBI |
(Semple et al., 2017b) | mice | Moderate/severe | Single | MWM | Reduced cognition in TBI | |
(Bajwa et al., 2016) | mice | moderate | Single | MWM | Severe cognitive decline | |
(Sebastian et al., 2013b) | rat | Moderate | single | RAM | Reduced short term working memory in TBI, no change in long term reference memory | |
(Song et al., 2016b) | mice | mild | single | RAM | Reduced working memory in TBI | |
FPI | (Shultz et al., 2015) | rat | severe | single | MWM | Reduced cognition 12weeks post TBI |
(Johnstone et al., 2015) | rat | moderate | single | MWM | Cognitive decline in TBI | |
(Webster et al., 2015) | rat | mild | repeated | MWM | Chronic reduced cognition in TBI | |
(Wright et al., 2016a) | rat | mild | repeated | MWM | Reduced cognition in TBI | |
(Shultz et al., 2014) | mice | moderate | Single | Y maze | Reduced spatial recognition in TBI |