Figure 4. The lack of LPA₂ results in reduced secondary damage after SCI.

(A) Quantification of myelin sparing at various distances rostral and caudal to the injury epicenter. (B, C) Representative micrographs of spinal cord tissue at the injury showing myelin sparing at the injury epicenter in WT (B) and LPA₂ deficient (C) mice. (*p<0.05, #p<0.01 vs WT; n=12 for WT and 11 for LPA₂ deficient mice). Error bars indicate SEM. Scale bar=500 μm. (D-E) Quantification of microglia, peripheral macrophages and neutrophils in the contused spinal cord of WT and LPA2 deficient mice at day 7 post-injury. (n=4 per group)