Figure 1. Phenotype and cytokine profile of Th17^CD39+ cells.

(A) Lymphocytes were gated based on their FSC and SSC patterns. CD4⁺ lymphocytes and IL-17⁺ cells within them were subsequently gated. CD39⁺ cells within CD4⁺IL-17⁺ lymphocytes are also shown. Representative plots from one HS. (B) Mean+SEM frequency of circulating Th17^CD39+ and Th17^CD39- cells positive for CD69, CD44, CD25, CD73, CD161, FOXP3, CCR6, IL-23R and RORC (n=16 HS). (C) Mean+SEM frequency of IFNγ, TNF-α, IL-10 and TGF-β producing cells amongst Th17^CD39+ and Th17^CD39- cells (n=11 HS). *: P≤0.05; **: P≤0.01; ***: P≤0.001.