2.

非实性肺小结节良恶性组间单因素分析结果

Demographic data, serum tumor markers and imaging characteristics of the non-solid lung nodules in benign and malignant groups

Characteristics	Study cohort (n=362)			Derivation set (n=242)
	Benign (n=49)	Malignant (n=313)	P	Benign (n=33)	Malignant (n=209)	P
*Applying Fisher exact method.
Demographic data
Age (Mean±SD, yr)	47.8±7.3	56.4±11.2	< 0.001	48.0±7.9	56.9±11.3	< 0.001
Male (%)	42.9 (21/49)	49.2 (154/313)	0.409	48.5 (16/33)	50.2 (105/209)	0.851
Smoking history (%)	24.5 (12/49)	28.1 (88/313)	0.598	27.3 (9/33)	28.7 (60/209)	0.865
Family history of lung cancer (%)	16.3 (8/49)	19.2 (60/313)	0.636	15.2 (5/33)	19.6 (41/209)	0.543
History of malignancy (%)	2.0 (1/49)	4.5 (14/313)	0.683	0 (0/33)	4.3 (9/209)	0.472
Serum tumor markers
CEA (Mean±SD, ng/mL)	1.66±0.81	3.20±1.79	< 0.001	1.72±0.73	3.20±1.80	< 0.001
Cyfra21-1 (Mean±SD, ng/mL)	1.94±0.69	2.58±0.94	< 0.001	1.77±0.67	2.53±0.89	< 0.001
Imaging characteristics
Maximum diameter (Mean±SD, cm)	1.66±0.62	1.77±0.74	0.293	1.64±0.63	1.70±0.74	0.641
Diameter of the solid component (Mean±SD, cm)	0.33±0.36	0.67±0.57	< 0.001	0.29±0.35	0.64±0.58	< 0.001
CTR≥50% (%)	20.4 (10/49)	39.3 (123/313)	0.011	18.2 (6/33)	40.2 (84/209)	0.015
Located on upper lobe (%)	55.1 (27/49)	56.9 (178/313)	0.816	60.6 (20/33)	57.9 (121/209)	0.769
Spiculation (%)	20.4 (10/49)	36.1 (113/313)	0.031	24.2 (8/33)	35.4 (74/209)	0.208
Lobulation (%)	34.7 (17/49)	67.7 (212/313)	< 0.001	36.4 (12/33)	62.7 (131/209)	0.004
Calcification (%)	6.1 (3/49)	0.6 (2/313)	0.019*	6.1 (2/33)	0.5 (1/209)	0.050*
Cavitation (%)	4.1 (2/49)	5.4 (17/313)	0.961	6.1 (2/33)	5.7 (12/209)	1.000
Clear margin (%)	75.5 (37/49)	63.3 (198/313)	0.095	75.8 (25/33)	64.1 (134/209)	0.190
Pleural retraction sign (%)	6.1 (3/49)	18.8 (59/313)	0.028	9.1 (3/33)	21.1 (44/209)	0.106
Emphysema (%)	10.2 (5/49)	7.0 (22/313)	0.621	12.1 (4/33)	8.6 (18/209)	0.745