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. 2019 Jan 21;9:3095. doi: 10.3389/fimmu.2018.03095

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Copyright © 2019 Du and Wei.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Interaction between NK cells and GC. NK cells display a suppressive phenotype with fewer activating receptors (NKG2D, NKp30, NKp46) and higher expression of PD-1 in GC patients. In addition, NK cells secret fewer cytokines (IFN-γ, IL-2, TNF-α, IL-12), and the ability to release perforins and granzymes is decreased. Meanwhile, GC cells downregulate the expression of MICA/B, ULBP, and B7H6 to avoid NK cell-mediated innate immunity. GC cells can also release some cytokines, including IL-10, TGF-β, and PGE2, and recruit MDSCs and Treg cells to suppress NK cell activity.