Table 2.

Crosstalk: different types of crosstalk added to the model.

#	Involved components	Description	Source
1	Snf1, Mth1, Std1	Active Snf1 prevents inactivation of Mth1 and Std1	Gadura et al., 2006; Pasula et al., 2007
2	Snf1, Std1	Std1 stimulates the Snf1 kinase activity	Hubbard et al., 1994; Tomás-Cobos and Sanz, 2002; Kuchin et al., 2003
3	Reg1, Glc7, Yck1, Yck2	Reg1-Glc7 acts as an upstream activator of Yck1 and Yck2	Gadura et al., 2006
4	PKA complex, Sak1	PKA complex phosphorylates Sak1	Barrett et al., 2012
5	Snf1, PKA complex	PKA complex negatively regulates the Snf1 pathway (Sak1 independent)	Barrett et al., 2012
6	Snf1, Msn2	Snf1 can phosphorylate Msn2	De Wever et al., 2005
7	PKA complex,	glucose activation of the PKA complex pathway	Castermans et al., 2012
	Glc7, Reg1	is required for activation of PP1 (Glc7-Reg1)
8	Snf1, Cyr1	Snf1 deactivates Cyr1 by phosphorylation	Nicastro et al., 2015
9	PKA complex, Rgt1	Bcy1 phosphorylates Rgt1 under high “glucose” conditions	Kim et al., 2006; Jouandot et al., 2011; Roy et al., 2013