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. 2019 Jan 27;12(4):602–613. doi: 10.1016/j.tranon.2019.01.001

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© 2019 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

NFκB signal IKKB inhibitor enhanced P induced cytotoxicity. KG1a cells were pretreated with different concentrations of IKKB inhibitor (IKKBi) for 1 hour, followed by 2 μM of P treatment for 48 hours. The cells were stained with Annexin V and 7AAD and cell apoptosis was detected using flow cytometry. A. Representative flow figures are shown. B. Data are means ± SD (duplicate). *P < .05; ***P < .001; ^P < .05; ^^P < .01; ^^^P < .001 compared to pevonedistat treatment by one-way ANOVA followed by Newman–Keuls Multiple Comparison Test.