Table II.

Serum IL-6, tissue concentrations of MPO and MDA, LDH levels in BAL, serum levels of amylase, and the other biochemical parameters at 24 h in animals with or without ANP treated with saline or ethyl pyruvate (data are given as mean ± SEM)

Parameter	Sham + saline N = 10	Sham + EP N = 10	ANP + saline N = 9	ANP + EP N = 13
Amylase [U/l]	1632 ±22	1570 ±33	12300 ±380**	9128 ±580**,*α
Glucose [mg/dl]	77 ±15	81 ±12	101 ±8	119 ±15
Urea [mg%]	18 ±4	17 ±3	55 ±7*	22 ±3*α
Creatinine [mg%]	0.45 ±0.1	0.44 ±0.1	0.46 ±0.1	0.45 ±0.1
ALT [U/l]	67 ±7	69 ±8	220 ±17*	142 ±12**,*α
Calcium [mg%]	8.9 ±0.2	9.1 ±0.2	8 ±0.2*	8.5 ±0.2*α
BAL LDH [U/l]	364 ±22	369 ±24	790 ±82*	313 ±26
IL-6 [pg/ml]	870 ±65	925 ±56	5470 ±280**	2250 ±180**,*α
Pancreas MDA	0.35 ±0.03	0.33 ±0.03	1.05 ±0.04*	0.5 ±0.06
Pancreas MPO [U/mg total protein]	0.26 ±0.01	0.23 ±0.02	0.97 ±0.03*	0.35 ±0.04
Pancreas MPO [kU/mg MPO protein]	2.2 ±0.1	2.3 ±0.1	8.2 ±0.3*	3.23 ±0.4
Lung MDA	0.26 ±0.02	0.28 ±0.02	0.90 ±0.04**	0.87 ±0.04**
Lung MPO [U/mg total protein]	3.3 ±0.03	3.3 ±0.03	5.3 ±0.04*	3.1 ±0.04
Lung MPO [kU/mg MPO protein]	28 ±5	26 ±4	48 ±5*	33.9 ±6

ALT – alanine aminotransferase, ANP – acute necrotizing pancreatitis, BAL – bronchoalveolar lavage, EP – ethyl pyruvate, LDH – lactate dehydrogenase, MDA – malondialdehyde, MPO – myeloperoxidase.

^*p < 0.05 compared with other groups

^**p < 0.01 compared with sham groups

^*αp < 0.05 compared with ANP + saline group.