Table 2.

Differentially Methylated Genes and the Enriched Gene Networks.^a

Comparison	#DMR	#Differentially Methylated Genes	Top Major Networks (Significance Score = −log10[P value])
IUGR vs AGA	1015	191	Cell-to-cell signaling and interaction, cellular assembly and organization, nervous system development and function (52) Connective tissue disorders, dermatological diseases and conditions, hereditary disorder (37) Cell-to-cell signaling and interaction, cellular assembly and organization, nervous system development and function (37) Lipid metabolism, small molecule biochemistry, cell-to-cell signaling and interaction, cellular assembly and organization, nervous system development and function (33) Cardiac hypoplasia, cardiovascular disease, developmental disorder (32)
LGA vs AGA	906	171	Connective tissue disorders, dermatological diseases and conditions, hereditary disorder (38) Cancer, organismal injury and abnormalities, reproductive system disease (37) Connective tissue development and function, embryonic development, organ development (32) Connective tissue disorders, inflammatory disease, skeletal and muscular disorders (32) Cellular assembly and organization, cellular function and maintenance, cell death, and survival (32)
LGA vs IUGR	1022	172	Cell morphology, cellular assembly, and organization, cancer (42) Neurological disease, cell morphology, organismal injury, and abnormalities (33) Nervous system development and function, tissue morphology, embryonic development (31) Connective tissue disorders, dermatological diseases and conditions, behavior (31) Small molecule biochemistry, cancer, neurological disease (31)

Abbreviations: AGA, appropriate for gestational age; DMR, differentially methylated region; IL10, interleukin 10; IUGR, intrauterine growth restriction; LGA, large for gestational age.

^aThe number of DMR and DMR genes found between each comparison group and the top major networks represented by those DMR.