Table 5.

Genomic Regions Enrichment of Annotations Tool (GREAT) Analyses.^a

Comparison	Hyper Raw P Value	Hyper FDR Q-val	Hyper Fold Enrichment	Significant Functional Pathways
IUGR vs. AGA	4.9137 × e− 5	5.5279 × e− 2	4.9320	Podosome (GO cellular component)
	3.0438 × e− 7	2.4299 × e− 3	16.4984	Protein RNF187 (TreeFam)
	3.3197 × e− 6	1.3250 × e− 2	11.5156	Rho-related GTP-binding protein RhoV RhoU (Tree Fam)
LGA vs. AGA	2.6922 × e− 5	3.0287 × e− 2	2.6931	Neuron projection terminus (GO cellular component)
	6.9863 × e− 5	3.9298 × e− 2	2.6610	Axon terminus (GO cellular component)
	3.0930 × e− 6	2.2557 × e− 2	5.4859	Abnormal placental physiology (mouse phenotype)
	8.8175 × e− 6	3.2153 × e− 2	4.5579	Abnormal extraembryonic tissue physiology (mouse phenotype)
	2.1239 × e− 5	5.1632 × e− 2	56.7979	Abnormal organ of Corti supporting cell proliferation (mouse phenotype)
	2.6665 × e− 5	4.8617 × e− 2	8.3369	Abnormal placental transport (mouse phenotype)
	3.1784 × e− 5	4.6360 × e− 2	8.1083	Enlarged inguinal lymph nodes (mouse phenotype)
	3.7734 × e− 5	4.5866 × e− 2	47.0611	Increased organ of Corti supporting cell number (mouse phenotype)
	3.7981 × e− 5	3.9571 × e− 2	4.2479	Increased thyroid-stimulating hormone level (mouse phenotype)
	4.2729 × e− 5	3.8953 × e− 2	4.5547	Increased circulating thyroid-stimulating hormone level (mouse phenotype)
	4.5548 × e− 5	3.6909 × e− 2	3.8834	Maternal imprinting (Mouse phenotype)
	2.1239 × e− 5	4.7427 × e− 2	56.7979	Familial retinoblastoma, bilateral retinoblastoma (disease ontology)
LGA vs. IUGR	2.7542 × e− 7	9.3671 × e− 4	10.5601	CTD phosphatase activity (GO molecular function)
	1.8216 × e− 6	1.5959 × e− 2	16.9861	Insulin receptor signaling pathway via phosphatidylinositol 3-kinase cascade (GO biological process)
	5.8649 × e− 6	2.5691 × e− 2	10.5528	Gonadal mesoderm development (GO biological process)
	1.0997 × e− 5	3.2115 × e− 2	9.5746	Regulation of glycogen (starch) synthase activity (GO biological process)
	2.2774 × e− 5	4.9881 × e− 2	10.9015	Positive regulation of glycogen (starch) synthase activity (GO biological process)
	2.5493 × e− 5	4.4669 × e− 2	6.0198	Fibril organization (GO biological process)
	5.7476 × e− 6	2.0958 × e− 2	85.9298	Decreased activity of parathyroid (mouse phenotype)
	6.2276 × e− 6	1.5139 × e− 2	10.4557	Absent pulmonary valve, aortic valve cusps (mouse phenotype)
	6.6773 × e− 6	9.7396 × e− 3	8.4136	Abnormal placental transport (mouse phenotype)
	2.2514 × e−5	2.7366 × e−2	5.4164	Hypocalcemia (mouse phenotype)
	2.5252 × e− 5	2.6309 × e− 2	10.7019	Delayed eyelid fusion (mouse phenotype)
	3.0255 × e− 5	2.7582 × e− 2	10.3603	Abnormal compact bone lamellar structure (mouse phenotype)
	4.2905 × e− 5	3.4767 × e− 2	2.4935	Abnormal lens development (mouse phenotype)
	6.7228 × e− 5	4.9029 × e− 2	7.1910	Abnormal nucleus accumbens morphology (mouse phenotype)
	4.7763 × e− 8	2.8572 × e− 4	13.0042	Decreased serum estradiol (human phenotype)
	4.7763 × e− 8	2.8572 × e− 4	13.0042	Rhabdomyolysis, acute (human phenotype)
	5.5481 × e− 8	1.1063 × e− 4	12.7767	Prominent midface (human phenotype)
	5.1024 × e− 7	7.6306 × e− 4	9.8041	Peripheral hypomyelination (human phenotype)
	1.1858 × e− 6	1.4186 × e− 3	4.1977	Microcornia (human phenotype)
	1.6302 × e− 6	1.6253 × e− 3	8.5096	Genu recurvatum (human phenotype)
	4.7590 × e− 6	4.0669 × e− 3	3.7764	Congenital cataract (human phenotype)
	1.2228 × e− 5	9.1433 × e− 3	29.0708	Intracerebral calcification on CT scan (human phenotype)
	1.6101 × e− 5	1.0702 × e− 2	5.6358	Rhabdomyolysis (human phenotype)
	1.7984 × e− 5	1.0758 × e− 2	6.2966	Hypomyelination (human phenotype)
	6.2186 × e− 5	3.3818 × e− 2	4.7927	Abnormal formation of myelin sheaths (human phenotype)
	8.7600 × e− 5	4.3669 × e− 2	5.8403	Facial muscle weakness, mild (human phenotype)
	1.4132 × e− 6	3.1556 × e− 3	13.1098	Gonadoblastoma (disease ontology)
	1.8216 × e− 6	2.0338 × e− 3	16.9861	Congenital mesoblastic nephroma (disease ontology)
	4.4680 × e− 6	3.3257 × e− 3	14.5354	Phyllodes tumor (disease ontology)
	4.5160 × e− 5	2.5211 × e− 2	6.4282	Cherubism (disease ontology)
	5.5084 × e− 5	2.4601 × e− 2	5.4440	Sertoli cell-only syndrome (disease ontology)
	8.0341 × e− 5	2.9900 × e− 2	2.7127	Mixed cell type cancer (disease ontology)
	4.5886 × e− 5	1.2940 × e− 2	9.6106	Trans, trans-farnesyl diphosphate biosynthesis (BioCyc pathway)
	1.8216 × e− 6	1.5187 × e− 2	16.9861	TS8_mural trophectoderm (MGI expression)
	7.6734 × e− 6	3.1986 × e− 2	8.2531	TS21_perioptic mesenchyme (MGI expression)
	1.0616 × e− 5	2.9503 × e− 2	12.4855	TS12_cavities (MGI expression)

Abbreviations: AGA, appropriate for gestational age; IUGR, intrauterine growth restriction; LGA, large for gestational age; GO, gene ontology; GTP, trimeric G proteins; FDR, false discovery rate; CTD, C-terminal domain; MGI, mouse gene informatics.

^aSignificant functional pathways that were enriched in comparisons between IUGR versus AGA, LGA versus AGA, and LGA versus IUGR using GREAT, along with hyper raw P values, hyper FDR Q-values, and hyper fold enrichment values.