Table 6.
STRING Protein-Protein Interaction Network Analyses.a
| Comparison | Count In Network | False Discovery Rate | Top Functional Enrichments |
|---|---|---|---|
| IUGR vs AGA | 29 | 1.93d-14 | Homophilic cell adhesion via plasma membrane adhesion molecules (GO Biological Process) |
| 30 | 4.58 × e− 13 | Cell-cell adhesion via plasma-membrane adhesion molecules (GO Biological Process) | |
| 143 | 6.34 × e− 09 | System development (GO Biological Process) | |
| 154 | 5.85 × e− 08 | Multicellular organismal development (GO Biological Process) | |
| 43 | 5.85 × e− 08 | Cell-cell adhesion (GO Biological Process) | |
| 43 | 7.29 × e− 05 | Calcium ion binding (GO Molecular Function) | |
| 152 | 0.000657 | Plasma membrane (GO Cellular Component) | |
| 154 | 0.000657 | Cell periphery (GO Cellular Component) | |
| 176 | 0.00171 | Intrinsic component of membrane (GO Cellular Component) | |
| 68 | 0.00171 | Cell projection (GO Cellular Component) | |
| 169 | 0.0051 | Integral component of membrane (GO Cellular Component) | |
| 11 | 0.00244 | Protein digestion and absorption (KEGG pathways) | |
| 10 | 0.0131 | Pancreatic secretion (KEGG pathways) | |
| 9 | 0.0281 | ECM-receptor interaction (KEGG pathways) | |
| LGA vs AGA | 18 | 0.00292 | Regulation of cellular response to growth factor stimulus (GO Biological Process) |
| 62 | 0.00656 | Nervous system development (GO Biological Process) | |
| 64 | 0.00656 | Regulation of developmental process (GO Biological Process) | |
| 69 | 0.00806 | Regulation of multicellular organismal process (GO Biological Process) | |
| 93 | 0.00873 | System development (GO Biological Process) | |
| 119 | 1.27 × e− 05 | Metal ion binding (GO Molecular function) | |
| 151 | 0.000262 | Ion binding (GO Molecular function) | |
| 30 | 0.00647 | Calcium ion binding (GO Molecular function) | |
| 217 | 0.00692 | Binding (GO Molecular function) | |
| 111 | 0.0338 | Protein binding (GO Molecular function) | |
| 12 | 0.0249 | Cytoplasmic side of plasma membrane (GO cellular component) | |
| 50 | 0.0249 | Cell projection (GO cellular component) | |
| 32 | 0.0249 | Neuron projection (GO cellular component) | |
| 37 | 0.0261 | Neuron part (GO cellular component) | |
| 204 | 0.0262 | Cytoplasm (GO cellular component) | |
| LGA vs IUGR | 27 | 7.68 × e− 13 | Hemophilic cell adhesion via plasma membrane adhesion molecules (GO Biological Process) |
| 26 | 7.41 × e− 10 | Cell-cell adhesion via plasma-membrane adhesion molecules (GO Biological Process) | |
| 149 | 1.22 × e− 07 | Multicellular organismal development (GO Biological Process) | |
| 92 | 2.3 × e− 07 | Anatomical structure morphogenesis (GO Biological Process) | |
| 162 | 2.3 × e− 07 | Developmental process (GO Biological Process) | |
| 46 | 7.38 × e− 07 | Calcium ion binding (GO Molecular function) | |
| 137 | 0.00367 | Metal ion binding (GO Molecular function) | |
| 138 | 0.00412 | Cation binding (GO Molecular function) | |
| 171 | 1.46 × e− 09 | Cell periphery (GO cellular component) | |
| 167 | 3.43 × e− 09 | Plasma membrane (GO cellular component) | |
| 70 | 0.000131 | Cell projection (GO cellular component) | |
| 50 | 0.00111 | Cell junction (GO cellular component) | |
| 84 | 0.00192 | Plasma membrane part (GO cellular component) | |
| 10 | 0.0104 | Protein digestion and absorption (KEGG pathways) |
Abbreviations: AGA, appropriate for gestational age; IUGR, intrauterine growth restriction; LGA, large for gestational age; GO, gene ontology; KEGG, Kyoto encyclopedia of genes and genomes.
aTop functional enrichments in IUGR versus AGA, LGA versus AGA, and LGA versus IUGR comparisons using STRING, along with counts in network and false discovery rate values.