Table 7.
Differentially Methylated Genes in IUGR and LGA Groups Compared to AGA in Metabolic, Cardiovascular, and Inflammatory Pathways.a
| Comparison Groups | Metabolic Genes | Cardiovascular Genes | Inflammatory Genes |
|---|---|---|---|
| IUGR versus AGA | |||
| PCSK1N | PTGIR b | IL10 b | |
| KCNAB2 | NTSR1 b | CD28 | |
| KCND1 | ACE | AZU1 | |
| BLK | NPY | IL3RA | |
| PTPRN2 b | NOS3 | MARCH1 | |
| GK b | CASZ1 b | LRBA | |
| GFPT1 | CD38 | ||
| AGMO | IL32 | ||
| RPH3AL b | |||
| LGA versus AGA | |||
| PTPRN2b | VEGFC | IL10 b | |
| ANKRD23 | PTGIR b | ||
| RIMS1 | CASZ1 b | ||
| GAD2 | CDH13 | ||
| PNPLA7 | NTSR1 b | ||
| GKb | |||
| RPH3ALb | |||
| KCNT1 | |||
| KCNG2 | |||
| BAIAP2 | |||
| LEPR |
Abbreviations: AGA, appropriate for gestational age; IUGR, intrauterine growth restriction; LGA, large for gestational age.
aSelected genes found to be differentially methylated in IUGR and LGA groups compared to controls who have been described as important in human metabolic, cardiovascular, and inflammatory pathways.
bDifferential methylation in both IUGR and LGA compared to AGA.