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. 2018 Dec 20;62(2):641–653. doi: 10.1021/acs.jmedchem.8b01327

Figure 4.

Figure 4

Systemic sc administration of 6-amino acid- and 6-dipeptide-substituted derivatives produces antinociception via activation peripheral receptors in the writhing assay in mice. Antinociceptive effects of 2b (50 μg/kg), 8b (50 μg/kg), 10b (200 μg/kg), 18b (50 μg/kg), 19b (50 μg/kg), and 23a (200 μg/kg) were antagonized by sc co-administration with naloxone methiodide (NLXM, 1 mg/kg) in the acetic acid-induced writhing assay in mice at 30 min after drug administration. Values are shown as mean of writhes ± SEM (n = 6–7 mice per group). ***P < 0.001 vs control group; #P < 0.05, ##P < 0.01 and ###P < 0.001 vs agonist treated group, ANOVA with Tukey’s post hoc test.