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Format and signal amplification strategy of the ultrasensitive HIV p24 lateral flow assay developed by Loynachan et al. Porous Pt core–shell nanoparticles catalyzed the precipitation of CN/DAB, amplifying visual signal and resulting in improved detection limits and an ultrabroad dynamic range. Figure adapted from ref (435). Copyright 2018 American Chemical Society (https://pubs.acs.org/page/policy/authorchoice_ccby_termsofuse.html).
