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. 2018 Dec 12;62(2):699–726. doi: 10.1021/acs.jmedchem.8b01413

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Copyright © 2018 American Chemical Society

This is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.

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Screening of third generation of degraders. (A) Western-blot analysis of BRD9 and BRD7 levels after treatment of HeLa cells with 1 μM compounds for 4 h before harvesting. (B) Western blot analysis of BRD9 and BRD7 levels after treatment of RI-1 cells with 1 μM compounds for 2 h before harvesting. (C) Western blot analysis of BRD9 and BRD7 levels after treatment of RI-1 cells with 1 μM 7, 26, 46, and 51 for 2 and 8 h before harvesting. Intensity values were quantified as described in the Experimental Section.