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. Author manuscript; available in PMC: 2019 Jan 28.
Published in final edited form as: Arch Toxicol. 2018 Apr 3;92(6):1969–1981. doi: 10.1007/s00204-018-2196-x

Fig. 4.

Fig. 4

Effect of metabolism mediated by CYP3A4, 3A5, and 2D6 on dronedarone-induced cell cycle perturbation. a Flow cytometric analysis for cell cycle distribution. Histograms shown were DNA content analyses for HepG2 cells treated with the indicated concentrations of dronedarone for 24 h. b bar graph depicts the mean percentage of each cell cycle phase ± SD from three independent experiments. *p < 0.05 compared with DMSO control. c, d Expression of cell cycle regulators were determined by Western blotting. GAPDH was used as a loading control. Similar results were obtained from three independent experiments. d Intensities of bands were normalized to the amount of GAPDH. *p < 0.05 versus treatment of DMSO vehicle control