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. 2019 Jan 28;19:35. doi: 10.1186/s12886-019-1044-y

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Baseline data of type 1 diabetic (T1D) rats included in the efficacy study of NTX-001 formulation. Histograms represent means ± SEM for (a) blood glucose (mg/dL), (b) Schirmer 1 test values (mm), and (c) corneal surface sensitivity as measured force (g/mm²) using a Cochet-Bonnet aesthesiometer. Data were analyzed using a two-tailed Student’s t-test. Values differed significantly between normal rats (N) and T1D animals at p < 0.0001 (****). Data reveal that T1D rats were hyperglycemic, had dry eye, and decreased corneal surface sensitivity