Table 5.
The previous studies reporting severe RP after radiotherapy in patients with IPF
| Number of Patients | Median follow-up (month, range) | Treatment | Median total dose | Grade ≥ 4 RP | |
|---|---|---|---|---|---|
| Yamashita et al. | 13 | 14.7 (0.3–76.2) | SBRT | 48.0 Gy | 7 (53.8%) |
| Lee et al. | 14 | 15.5 (6.1–40.9) | 3DCRT | 56.9 Gy | 5 (35.7%) |
| Yamaguchi et al. | 16 | – | SBRT | 48.0 Gy | 2 (12.5%) |
| Ono et al. | 16 | 12.0 (4–39) | PBT | 80.0 Gy (RBE) | 1 (6.3%) |
| Current study | 30 | 11.0 (2–51) | X-raya/PBT | 60.0 Gy | 18.2% (4/22) in X-ray 0% (0/8) in PBT |
RP radiation pneumonitis, IPF idiopathic pulmonary fibrosis, SBRT stereotactic body radiation therapy, 3DCRT 3-dimensional conformal radiation therapy, PBT proton beam therapy
aX-ray treatment includes 3DCRT, SBRT, and intensity-modulated radiation therapy (IMRT)