Table 1.

Case report details and circumstances of death including SUDEP classification per Nashef 2012 criteria [5].

Age of onset, age of death	Epilepsy diagnosis, etiology, MRI and EEG results	Seizure types	Medications trialed	Circumstances of death, SUDEP classification
13, 24	Generalized onset; presumptive genetic etiology (brother and father with similar seizure histories). MRI normal. EEG: 3 Hz spike and wave	Generalized onset, tonic clonic	Intermittent zonisamide and levetiracetam use. Cannabis including vaped, smoked, and tincture forms, with tincture use at time of death was 2:1 CBD:THC	In setting of 80 hour work week and over a year seizure free, left epilepsy clinic, went to vehicle, did not start it and was found deceased in car. Compliance on medications was varied with known tendency to dose traditional anti-seizure medications prior to clinic visits but otherwise skip dosing. No post mortem blood work on medication levels. Gene test results appear in the appendix data with – among others – heterozygous changes in CACNA1B, CACNA1H, CACNA2D2. SUDEP classification: probable SUDEP (post mortem data unavailable)
22, 27	Focal onset. History of viral encephalitis, MRI with right pituitary prolactinoma. Prior EEG: right temporal sharp waves.	Focal to bilateral generalized tonic–clonic seizures	Historically used zonisamide, oxcarbazepine, levetiracetam, though discontinued prior to final presentation. Was using CBD tablets dosed at 35 mg nightly.	Found unresponsive and cyanotic in the shower, face and airway submerged under water, her hands were clutching hair, suggesting seizure may have occurred while washing hair. Pulseless in field, resuscitated. Urine toxin positive for cannabis. Progressed to fixed, dilated pupils and criteria consistent with brain death, support withdrawn at 48 h post arrival. Patient lowered conventional anti-seizure medications on her own and preferred CBD therapies. SUDEP classification: not SUDEP given drowning.