Table 1.
Proteins with High Expression in C3m–treated versus Control*
| Primary Protein Name | Protein Description† | Protein Teller Probability | Number of Quantified Peptides | %CV QC Pool | Average Fold Change, C3m vs. Control | P Value (One-Way ANOVA) |
|---|---|---|---|---|---|---|
| GDF15_HUMAN | Growth/differentiation factor 15† | 1 | 5 | 3.24 | 5.89 | 5.76E-08 |
| SQSTM_HUMAN | Sequestosome-1† | 1 | 5 | 4.94 | 4.02 | 8.34E-06 |
| SRXN1_HUMAN | Sulfiredoxin-1† | 0.97 | 2 | 15.57 | 3.61 | 0.013 |
| TRXR1_HUMAN | Thioredoxin reductase 1, cytoplasmic† | 1 | 6 | 0.58 | 2.02 | 1.08E-05 |
| GFPT1_HUMAN | Glucosamine–fructose-6-phosphate aminotransferase [isomerizing] 1 | 1 | 14 | 2.54 | 1.88 | 6.85E-04 |
| AK1C1_HUMAN | Aldo-keto reductase family 1 member C1† | 1 | 27 | 1.21 | 1.88 | 1.11E-06 |
| NQO1_HUMAN | NAD(P)H dehydrogenase [quinone] 1† | 1 | 7 | 1.26 | 1.86 | 0.031 |
| OAT_HUMAN | Ornithine aminotransferase, mitochondrial | 1 | 11 | 2.16 | 1.82 | 0.013 |
| RISC_HUMAN | Retinoid-inducible serine carboxypeptidase | 1 | 7 | 2.82 | 1.79 | 0.017 |
| AK1C2_HUMAN | Aldo-keto reductase family 1 member C2† | 1 | 5 | 1.47 | 1.78 | 5.97E-04 |
| FKBP4_HUMAN | FK506-binding protein 4 | 1 | 13 | 1.78 | 1.75 | 0.02 |
| AK1C3_HUMAN | Aldo-keto reductase family 1 member C3† | 1 | 8 | 2.33 | 1.70 | 3.36E-06 |
| NFU1_HUMAN | NFU1 iron-sulfur cluster scaffold homolog, mitochondrial | 0.98 | 2 | 8.27 | 1.69 | 0.02 |
| AAAT_HUMAN | Neutral amino acid transporter B(0) | 1 | 6 | 2.51 | 1.66 | 0.038 |
| SYAC_HUMAN | Alanyl-tRNA synthetase, cytoplasmic | 1 | 13 | 3.40 | 1.66 | 9.25E-05 |
| ACSL4_HUMAN | Long-chain fatty-acid–CoA ligase 4 | 1 | 4 | 11.03 | 1.66 | 6.70E-10 |
| CYBP_HUMAN | Calcyclin-binding protein | 1 | 5 | 4.14 | 1.64 | 0.024 |
| XPP3_HUMAN | Probable Xaa-Pro aminopeptidase 3 | 1 | 4 | 3.68 | 1.60 | 8.78E-06 |
| UFL1_HUMAN | E3 UFM1-protein ligase 1 | 1 | 5 | 2.50 | 1.56 | 0.002 |
| MAOX_HUMAN | NADP-dependent malic enzyme | 1 | 11 | 5.31 | 1.56 | 7.36E-05 |
| GSH0_HUMAN | Glutamate–cysteine ligase regulatory subunit† | 1 | 4 | 7.16 | 1.54 | 2.64E-06 |
| HS105_HUMAN | Heat shock protein 105 kD | 1 | 18 | 1.20 | 1.54 | 2.08E-05 |
| HS90A_HUMAN | Heat shock protein HSP 90-alpha | 1 | 51 | 1.43 | 1.52 | 3.08E-13 |
| RETST_HUMAN | All-trans-retinol 13,14-reductase | 1 | 6 | 4.84 | 1.52 | 2.15E-06 |
| HTAI2_HUMAN | Oxidoreductase HTATIP2 | 1 | 6 | 0.50 | 1.51 | 1.50E-08 |
| GSH1_HUMAN | Glutamate–cysteine ligase catalytic subunit† | 1 | 20 | 1.99 | 1.49 | 4.84E-04 |
Definition of abbreviations: C3m = 4-[[2-[[(3-cyanophenyl)methyl]thio]-4-oxothieno-[3,2-d]pyrimidin-3(4H)-yl]methyl]-benzoic acid; CV = coefficient of variation; QC = quality control.
*
Data were filtered to include protein quantified by two or more peptides, average fold change approximately 1.5 or more between C3m and control groups. P < 0.05 (one-way ANOVA across four treatment groups).
†
Putative Nrf2-dependent proteins.