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. 2019 Jan;60(1):117–127. doi: 10.1165/rcmb.2018-0105OC

Figure 5.

Figure 5.

Angiogenesis is stimulated in the mouse lung after pneumonectomy (PNX). (A) Graph showing the ratio of the weight of right lung cardiac lobe to mouse body weight (BW) 7 days after PNX (n = 7, mean ± SEM, *P < 0.05). (B) Hematoxylin and eosin (H&E)–stained remaining right cardiac lobe 7 days after left PNX (top). Scale bar: 25 μm. Graphs showing quantification of alveolar number (left bottom) and alveolar size (mean linear intercept [MLI], right bottom) in the remaining mouse lung right cardiac lobe 7 days after PNX (n = 7, mean ± SEM, *P < 0.05). (C) Micrographs showing blood vessel structures in the mouse right lung lobe 7 days after left PNX analyzed using the Microfil casting system (top). Scale bar: 1 mm. Graphs showing the quantification of blood vessel density (left bottom) and the number of branching points (right bottom, n = 7, mean ± SEM, *P < 0.05). (D) IB showing the protein levels of YAP1, Tie2, TEAD1, and β-actin in ECs isolated from mouse lungs 7 days after PNX (left). Graph showing the quantification of YAP1, Tie2, and TEAD1 protein levels in ECs isolated from mouse lungs 7 days after PNX (right, n = 4, mean ± SEM, *P < 0.05).