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Impairment of KLF4-mediated vasodilation by GSNO. Pulmonary artery rings were isolated from WT and KLF4-Tg mice, with or without NAC (10 mmol/L, 3 h) pretreatment, were exposed to GSNO (0.5 mmol/L, 12 h). (A) ACh induced vasodilatory responses; (B) SNP induced endothelium-independent dilation. *p < 0.05 vs. WT-Control group, #p < 0.05 vs. KLF4-Tg-Control group, †p < 0.05 vs. KLF4-Tg-GSNO group, by two-way repeated measures ANOVA followed by post-hoc tests. n = 5–8.
