Table 1.
Top 20 pathways with significance could be associated with the level of uric acid in different organs.
| ID | Description | Significant | Annotated | P value | Q value | Positive num. | Negative num. |
|---|---|---|---|---|---|---|---|
| ko03010 | Ribosome | 184/1937 | 288/7604 | 1.26E-44 | 3.37E-42 | 172 | 12 |
| ko04141 | Protein processing in the endoplasmic reticulum | 89/1937 | 172/7604 | 8.09E-14 | 1.09E-11 | 62 | 27 |
| ko00240 | Pyrimidine metabolism | 50/1937 | 106/7604 | 9.93E-07 | 8.89E-05 | 36 | 14 |
| ko04975 | Fat digestion and absorption | 24/1937 | 39/7604 | 1.99E-06 | 0.000134 | 21 | 3 |
| ko00520 | Amino sugar and nucleotide sugar metabolism | 27/1937 | 49/7604 | 8.96E-06 | 0.000481 | 19 | 8 |
| ko05110 | Vibrio cholerae infection | 28/1937 | 52/7604 | 1.11E-05 | 0.000494 | 14 | 14 |
| ko00230 | Purine metabolism | 68/1937 | 170/7604 | 1.88E-05 | 0.000721 | 38 | 30 |
| ko00480 | Glutathione metabolism | 28/1937 | 54/7604 | 2.80E-05 | 0.000941 | 21 | 7 |
| ko00983 | Drug metabolism (other enzymes) | 22/1937 | 39/7604 | 3.73E-05 | 0.001011 | 19 | 3 |
| ko03460 | Fanconi anemia pathway | 27/1937 | 52/7604 | 3.77E-05 | 0.001011 | 18 | 9 |
| ko03008 | Ribosome biogenesis in eukaryotes | 37/1937 | 81/7604 | 5.99E-05 | 0.001462 | 25 | 12 |
| ko00620 | Pyruvate metabolism | 23/1937 | 43/7604 | 7.72E-05 | 0.001727 | 10 | 13 |
| ko00330 | Arginine and proline metabolism | 28/1937 | 59/7604 | 0.000209 | 0.004278 | 17 | 11 |
| ko00500 | Starch and sucrose metabolism | 21/1937 | 40/7604 | 0.000223 | 0.004278 | 12 | 9 |
| ko03030 | DNA replication | 20/1937 | 38/7604 | 0.000301 | 0.00538 | 16 | 4 |
| ko00900 | Terpenoid backbone biosynthesis | 14/1937 | 23/7604 | 0.000342 | 0.005742 | 10 | 4 |
| ko00561 | Glycerolipid metabolism | 26/1937 | 56/7604 | 0.000534 | 0.008435 | 19 | 7 |
| ko04972 | Pancreatic secretion | 40/1937 | 98/7604 | 0.000587 | 0.008748 | 33 | 7 |
| ko04113 | Meiosis (yeast) | 26/1937 | 59/7604 | 0.001403 | 0.019819 | 19 | 7 |
| ko04111 | Cell cycle (yeast) | 29/1937 | 70/7604 | 0.002443 | 0.032791 | 24 | 5 |
| ko00970 | Aminoacyl-tRNA biosynthesis | 21/1937 | 47/7604 | 0.003207 | 0.03985 | 12 | 9 |
| ko00510 | N-Glycan biosynthesis | 22/1937 | 50/7604 | 0.003266 | 0.03985 | 19 | 3 |
| ko02020 | Two-component system | 10/1937 | 17/7604 | 0.003564 | 0.041593 | 6 | 4 |
| ko04110 | Cell cycle | 45/1937 | 123/7604 | 0.003905 | 0.043679 | 42 | 3 |
| ko04210 | Apoptosis | 33/1937 | 85/7604 | 0.004440 | 0.045337 | 21 | 12 |
| ko03440 | Homologous recombination | 14/1937 | 28/7604 | 0.004476 | 0.045337 | 10 | 4 |
| ko00100 | Steroid biosynthesis | 11/1937 | 20/7604 | 0.004560 | 0.045337 | 11 | 0 |
| ko04910 | Insulin signaling pathway | 48/1937 | 134/7604 | 0.004738 | 0.045421 | 19 | 29 |
| ko00564 | Glycerophospholipid metabolism | 35/1937 | 92/7604 | 0.005061 | 0.046841 | 23 | 12 |
| ko03060 | Protein export | 12/1937 | 23/7604 | 0.005410 | 0.048403 | 8 | 4 |