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. 2019 Jan 10;2019:5160565. doi: 10.1155/2019/5160565

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Copyright © 2019 Niclas C. Blessin et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Interindividual variations of TIGIT (green) and PD-1 (red) in 10 patients (P1-10) each with Hashimoto thyroiditis and sarcoidosis; two patients (P1 and P2) each with lichen sclerosus, IgG4 pancreatitis, and rheumatoid arthritis of (a) CD4⁺ helper T cells, (b) CD8⁺ cytotoxic T cells, and (c) FOXP3⁺ regulatory T cells. Relative expression refers to the fluorescence measurement in the tonsil germinal centre periphery (Ref. Gc. To.) set to 100%. The black bar shows the TIGIT : PD-1 expression ratio. In.: interfollicular area; Gc.: germinal centre; Gra.: granuloma; Interg.: intergranuloma; Lymphocytic in.: lymphocytic infiltration; To: tonsil; ^∗ p ≤ 0.05; ^∗∗ p ≤ 0.001; ^∗∗∗ p ≤ 0.0001; [n.s.]: not significant (p > 0.05).