Table 3.
Respiratory outcomes, mortality, and morbidity.
| Very preterm infants, < 33 weeks gestation (GA) | Extremely low birth weight infants, < 1000 g | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Variable, | 2008-2010 | 2011-2013 | 2014-2017 | p | p adjusted | 2008-2010 | 2011-2013 | 2014-2017 | p | p adjusted for |
| % or Median (IQR) | n = 229 | n = 194 | n = 217 | for GA | n = 53 | n = 52 | n = 37 | male sex and GA | ||
| Respiratory Outcomes | ||||||||||
| NICU intubation | 39 | 31 | 18 | <0.001†‡ | <0.001 | 92 | 73 | 51 | <0.001∗† | <0.001 |
| Pneumothorax | 5 | 3 | 2 | ns | ns | 17 | 10 | 0 | 0.01† | 0.018 |
| Chronic lung disease | 12 | 13 | 14 | ns | ns | 50 | 46 | 43 | ns | ns |
| Oxygen at discharge | 5 | 3 | 2 | ns | ns | 23 | 10 | 11 | ns | ns |
| Mortality and Morbidity | ||||||||||
| Mortality | 6 | 6 | 2 | ns | ns | 19 | 17 | 11 | ns | ns |
| Major intraventricular hemorrhage | 8 | 6 | 4 | ns | ns | 26 | 19 | 16 | ns | ns |
| Nosocomial infection | 8 | 5 | 4 | ns | ns | 26 | 15 | 16 | ns | ns |
| Severe retinopathy of prematurity | 6 | 3 | 4 | ns | ns | 25 | 12 | 24 | ns | ns |
| Necrotizing enterocolitis (NEC) | 5 | 5 | 2 | ns | ns | 19 | 13 | 8 | ns | ns |
| NEC / Spontaneous Intestinal perforation | 5 | 5 | 2 | ns | ns | 19 | 15 | 8 | ns | ns |
| NICU length of stay, days | 37 (21 - 63) | 35 (22 - 61) | 39 (24 - 61) | ns | 101 (69 - 116) | 86 (54 - 102) | 87 (64 - 107) | ns | ||
| Post menstrual age at discharge, weeks | 35.9 (34.6 - 38.0) | 35.9 (34.6 - 37.6) | 36.1 (35.3 - 38.1) | 0.008†‡ | 40.0 (35.9 - 42.1) | 38.4 (35.7 - 40.9) | 39.1 (37.7 - 42.1) | ns | ||
| Survival without major morbidity | 74 | 76 | 80 | ns | ns | 15 | 25 | 41 | 0.02† | 0.021 |
∗Statistically significant difference between 2008-2010 and 2011-2013.
†Statistically significant difference between 2008-2010 and 2014-2017.
‡Statistically significant difference between 2011-2013 and 2014-2017.