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. Author manuscript; available in PMC: 2019 Jan 28.
Published in final edited form as: J Cell Biochem. 2018 Jul 16;119(11):8830–8840. doi: 10.1002/jcb.27133

Figure 1. Global overexpression of Mdm2 causes a high bone volume phenotype and increases osteogenic differentiation.

Figure 1.

A. μCT imaging of Mdm2Tg vertebrae compared to wild type control. B. MDM2 overexpression increases mBMD of trabecular bone. C.-F. Mdm2 improves bone architecture with increases in BV/TV, Tb.N, decrease in Tb.Sp, and corresponding increase in Tb.Th. G. MDM2 overexpression enhances OB differentiation from BMSCs quantitated by mineralized nodules. H. Mdm2 overexpression increases Alkaline phosphatase colonies. Asterisk signifies statistical significance at p<0.05.