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. Author manuscript; available in PMC: 2019 Jan 28.
Published in final edited form as: J Mol Biol. 2008 Aug 6;382(5):1195–1210. doi: 10.1016/j.jmb.2008.07.088

Figure 9. Summary of Functional and Conformational Changes Observed in GAPDH in Response to Oxidative Stress.

Figure 9.

Tetrameric human GAPDH (pdb code 1u8f) is shown with BisANS sites incorporated to GAPDH shown only on one of the four subunits. The changes in BisANS incorporation sites that correlate with the level of oxidative stress and GAPDH activity in the NTg (left), H46R/H48Q (middle), G93A (right) models are shown. The amino acids involved in enzyme activity are indicated in black. All NTg sites are indicated by green dots, and sites gained with increased oxidative stress are indicated by red dots. The sites corresponding to doubly labeled peptides are circled.