Table 2.
Baseline Characteristics at First Visit With Obesity Subphenotype Data Available (Examinations 2 to 7, From 1979–1983 to 1998–2001), by Obesity Subphenotypes
| Characteristics (N = 4291 Participants) | Nonobese |
Obese |
||
|---|---|---|---|---|
| Metabolically Healthya (2349, 54.7%) | Metabolically Unhealthya (1323, 30.8%) | Metabolically Healthya (187, 4.4%) | Metabolically Unhealthya (432, 10.1%) | |
| Age, y | 42 (10) | 48 (10) | 45 (10) | 48 (9) |
| Women | 1480 (63) | 470 (36) | 108 (58) | 177 (41) |
| Current smoking | 806 (34) | 511 (39) | 48 (26) | 158 (37) |
| BMI, kg/m2 | 23.4 (21.4, 25.7) | 26.0 (24.0, 27.7) | 32.5 (31.4, 35.2) | 32.8 (31.4, 35.7) |
| Systolic blood pressure, mm Hg | 115 (14) | 131 (16) | 125 (16) | 134 (16) |
| Diastolic blood pressure, mm Hg | 74 (8) | 82 (9) | 80 (9) | 85 (9) |
| Hypertension (2014 JNC-8 definition) | 192 (8.2) | 560 (42.3) | 49 (26.2) | 236 (54.8) |
| Hypertension (2017 ACC/AHA definition) | 657 (28.0) | 1011 (76.4) | 107 (57.2) | 366 (84.7) |
| Use of antihypertensive medications | 65 (2.8) | 261 (19.7) | 22 (11.8) | 113 (26.2) |
| Total cholesterol, mmol/L | 5.1 (0.9) | 5.7 (1.1) | 5.1 (0.9) | 5.7 (1.0) |
| HDL-cholesterol, mmol/L | 1.4 (0.4) | 1.1 (0.3) | 1.3 (0.3) | 1.0 (0.3) |
| LDL-cholesterol, mmol/L | 3.3 (0.9) | 3.8 (1.0) | 3.4 (0.8) | 3.8 (0.9) |
| Triglycerides, mmol/L | 0.8 (0.6, 1.1) | 1.5 (1.0, 2.1) | 0.9 (0.7, 1.2) | 1.7 (1.3, 2.3) |
| Use of lipid-lowering drugs | 3 (0.1) | 30 (2.3) | 0 (0.0) | 8 (1.9) |
| Diabetes | 11 (0.5) | 94 (7.2) | 1 (0.6) | 58 (13.7) |
| Fasting glucose, mmol/L | 5.0 (4.8, 5.3) | 5.7 (5.3, 6.0) | 5.2 (5.0, 5.4) | 5.8 (5.3, 6.2) |
| History of CVD | 43 (1.8) | 95 (7.2) | 7 (3.7) | 30 (6.9) |
Data are mean (SD) or median (quartile 1, quartile 3) for continuous variables, and number (%) for categorical variables.
Abbreviations: ACC, American College of Cardiology; AHA, American Heart Association; JNC-8, Eighth Joint National Committee.
a
Definitions are provided in the Methods section.