Table 5.
Cross-Sectional Association of Obesity Subphenotypes and Subclinical Outcomes
| Outcomes | Events/n | Unadjusted OR (95% CI) | Adjusted OR (95% CI)a |
|---|---|---|---|
| Subclinical CVD score: examination 6 (1995–1998) | |||
| Metabolic status–BMI scoreb | 687/1949 | 1.77 (1.59–1.97) | 1.55 (1.38–1.75) |
| Dichotomized metabolic status–BMI score | |||
| High | 2.50 (2.06–3.03) | 1.98 (1.61–2.44) | |
| Low | 1.00 (reference) | 1.00 (reference) | |
| Obesity subphenotypes at examination 6 | |||
| MHNO | 227/893 | 1.00 (reference) | 1.00 (reference) |
| MHO | 42/149 | 1.15 (0.78–1.70) | 1.28 (0.85–1.93) |
| MUNO | 286/616 | 2.54 (2.04–3.16) | 1.95 (1.54–2.47) |
| MUO | 132/291 | 2.44 (1.85–3.21) | 2.26 (1.69–3.03) |
| CAC: examination 7 (1998–2001) | |||
| Metabolic status–BMI scoreb | 487/1107 | 2.61 (2.24–3.04) | 2.15 (1.82–2.53) |
| Dichotomized metabolic status–BMI score | |||
| High | 4.32 (3.32–5.61) | 3.24 (2.43–4.31) | |
| Low | 1.00 (reference) | 1.00 (reference) | |
| Obesity subphenotypes at examination 7 | |||
| MHNO | 146/504 | 1.00 (reference) | 1.00 (reference) |
| MHO | 41/95 | 1.86 (1.19–2.92) | 1.94 (1.18–3.19) |
| MUNO | 162/295 | 2.99 (2.21–4.03) | 1.92 (1.38–2.68) |
| MUO | 138/213 | 4.51 (3.21–6.34) | 3.81 (2.62–5.54) |
a
Adjusted for age, sex, and current smoking.
b
Metabolic status–BMI score is an average score calculated as the sum of scores corresponding to each metabolic–BMI status at each examination (MHNO = 1, MHO = 2, MUNO = 3, and MUO = 4) divided by the number of attended examinations. A high score is a score above the median.