Table 8.
Association of Obesity Subphenotypes and Outcomes During Follow-Up (From 1998–2001 to 2014)
| Outcomes | Obesity Subphenotypes at Examination 7 (in 1998–2001) |
||
|---|---|---|---|
| Events/n | Unadjusted HR (95% CI) | Adjusted HR (95% CI)a | |
| Type 2 diabetes | |||
| MHNO | 15/1191 | 1.00 (reference) | 1.00 (reference) |
| MHO | 13/220 | 4.77 (2.25–10.11)b | 4.69 (2.21–9.96)b |
| MUNO | 81/903 | 8.98 (5.15–15.66)b | 7.86 (4.47–13.82)b |
| MUO | 122/554 | 23.86 (13.85–41.11)b | 21.93 (12.68–37.94)b |
| Hypertension (2014 JNC-8 criteria) | |||
| MHNO | 364/1022 | 1.00 (reference) | 1.00 (reference) |
| MHO | 98/189 | 2.04 (1.54–2.70)b | 2.21 (1.66–2.94)b |
| MUNO | 203/374 | 2.58 (2.08–3.22)b | 2.30 (1.83–2.90)b |
| MUO | 119/210 | 2.84 (2.16–3.73)b | 2.85 (2.15–3.78)b |
| Hypertension (2017 ACC/AHA criteria) | |||
| MHNO | 419/847 | 1.00 (reference) | 1.00 (reference) |
| MHO | 86/133 | 1.97 (1.42–2.73)b | 1.98 (1.42–2.77)b |
| MUNO | 111/196 | 1.84 (1.38–2.46)b | 1.63 (1.20–2.20)b |
| MUO | 57/101 | 1.91 (1.29–2.83)b | 1.81 (1.21–2.71)b |
| CKD/microalbuminuria | |||
| MHNO | 129/848 | 1.00 (reference) | 1.00 (reference) |
| MHO | 22/162 | 0.86 (0.54–1.38) | 0.97 (0.60–1.58) |
| MUNO | 145/608 | 1.98 (1.53–2.55)b | 1.44 (1.10–1.89) |
| MUO | 127/431 | 2.59 (1.98–3.38)b | 2.19 (1.65–2.90)b |
| CVD | |||
| MHNO | 125/1169 | 1.00 (reference) | 1.00 (reference) |
| MHO | 29/227 | 1.22 (0.82–1.83) | 1.38 (0.92–2.07) |
| MUNO | 180/859 | 2.19 (1.75–2.76)b | 1.58 (1.25–2.00)b |
| MUO | 153/617 | 2.60 (2.05–3.29)b | 2.17 (1.71–2.76)b |
| Cancer mortality | |||
| MHNO | 67/1234 | 1.00 (reference) | 1.00 (reference) |
| MHO | 16/243 | 1.21 (0.70–2.09) | 1.26 (0.73–2.17) |
| MUNO | 109/1073 | 2.15 (1.59–2.92)b | 1.31 (0.96–1.79) |
| MUO | 67/752 | 1.80 (1.29–2.53)b | 1.36 (0.97–1.92) |
| Cardiovascular mortality | |||
| MHNO | 32/1234 | 1.00 (reference) | 1.00 (reference) |
| MHO | 6/243 | 0.96 (0.40–2.28) | 1.17 (0.49–2.81) |
| MUNO | 79/1073 | 3.28 (2.17–4.94)b | 1.63 (1.07–2.49) |
| MUO | 44/752 | 2.50 (1.58–3.94)b | 1.74 (1.10–2.75) |
| All-cause mortality | |||
| MHNO | 172/1234 | 1.00 (reference) | 1.00 (reference) |
| MHO | 34/243 | 1.01 (0.70–1.46) | 1.20 (0.83–1.73) |
| MUNO | 319/1073 | 2.37 (1.97–2.85)b | 1.37 (1.13–1.66)b |
| MUO | 184/752 | 1.88 (1.53–2.32)b | 1.40 (1.14–1.73)b |
Abbreviations: ACC, American College of Cardiology; AHA, American Heart Association; JNC-8, Eighth Joint National Committee.
a
Adjusted for age, sex, and current smoking.
b
Association was significant at the Bonferroni-adjusted α level (P < 0.007).