. 2018 Oct 18;104(3):738–752. doi: 10.1210/jc.2018-01321

Table 9.

Association of the Summary Score for Obesity Subphenotypes During Attended Examinations and Outcomes During Follow-Up (1998–2001 to 2011–2014) Among Participants With Complete Data From Baseline to Last Examination (1987–1991 to 1998–2001)

Outcomes	Obesity Subphenotypes During Adulthood (From 1979–1983 to 1998–2001)
Outcomes	Events/n	Unadjusted HR (95% CI)	Adjusted HR (95% CI)^a
Type 2 diabetes
Metabolic status–BMI score^b	186/2170	3.78 (3.15–4.53)^c	3.80 (3.14–4.59)^c
Dichotomized metabolic status–BMI score
High		10.59 (7.18–15.61)^c	10.32 (6.91–15.41)^c
Low		1.00 (reference)	1.00 (reference)
Hypertension (2014 JNC-8 criteria)
Metabolic status–BMI score^b	614/1328	1.93 (1.69–2.20)^c	1.86 (1.62–2.14)^c
Dichotomized metabolic status–BMI score
High		2.74 (2.16–3.46)^c	2.54 (1.99–3.25)^c
Low		1.00 (reference)	1.00 (reference)
Hypertension (2017 ACC/AHA criteria)
Metabolic status–BMI score^b	519/952	1.84 (1.54–2.18)^c	1.75 (1.46–2.11)^c
Dichotomized metabolic status–BMI score
High		2.52 (1.84–3.45)^c	2.30 (1.65–3.20)^c
Low		1.00 (reference)	1.00 (reference)
CKD/microalbuminuria
Metabolic status–BMI score^b	329/1478	1.58 (1.39–1.79)^c	1.42 (1.24–1.62)^c
Dichotomized metabolic status–BMI score
High		2.22 (1.75–2.81)^c	1.84 (1.43–2.38)^c
Low		1.00 (reference)	1.00 (reference)
CVD
Metabolic status–BMI score^b	380/2131	1.77 (1.59–1.96)^c	1.55 (1.39–1.72)^c
Dichotomized metabolic status–BMI score
High		2.71 (2.20–3.33)^c	2.13 (1.72–2.63)^c
Low		1.00 (reference)	1.00 (reference)
Cancer mortality
Metabolic status–BMI score^b	204/2478	1.40 (1.21–1.61)^c	1.13 (0.97–1.31)
Dichotomized metabolic status–BMI score
High		1.69 (1.29–2.23)^c	1.18 (0.89–1.57)
Low		1.00 (reference)	1.00 (reference)
Cardiovascular mortality
Metabolic status–BMI score^b	124/2478	1.95 (1.63–2.35)^c	1.55 (1.28–1.89)^c
Dichotomized metabolic status–BMI score
High		3.06 (2.10–4.46)^c	1.94 (1.33–2.84)^c
Low		1.00 (reference)	1.00 (reference)
All-cause mortality
Metabolic status–BMI score^b	555/2478	1.61 (1.48–1.76)^c	1.30 (1.19–1.42)^c
Dichotomized metabolic status–BMI score
High		2.32 (1.96–2.76)^c	1.55 (1.30–1.85)^c
Low		1.00 (reference)	1.00 (reference)

Abbreviations: ACC, American College of Cardiology; AHA, American Heart Association; JNC-8: Eighth Joint National Committee.

^{^a}

Adjusted for age, sex, and current smoking.

^{^b}

Metabolic status–BMI score is an average score calculated as the sum of scores corresponding to each metabolic–BMI status at each examination (MHNO = 1, MHO = 2, MUNO = 3, and MUO = 4) divided by the number of attended examinations. A high score is a score above the median.

^{^c}

Association was significant at the Bonferroni-adjusted α level (P < 0.007).