Table 4:
Change in outcome measures for effects of THC upon acute stress responses (data represent AUC relative to the pre-task post-drug baseline, except for task appraisals and performance measures which are raw scores, compared using Task*Group rmANOVAs). 1Analysis performed for 0 vs. 7.5mg THC (due to true baseline group difference in subjective distress for 12.5mg THC before task performance). Asterisks indicate significant outcomes (*p<0.05, **p<0.01, ***p<0.001). Symbols indicate difference from #0mg, §7.5mg (post-hoc Bonferroni test).
| Control | TSST | ||||||
|---|---|---|---|---|---|---|---|
| 0mg | 7.5mg | 12.5mg | 0mg | 7.5mg | 12.5mg | F(df) | |
| VAS | |||||||
| Subjective distress1 | −11.4±13.2 | 2.6±8.6 | (−56.0±39.7) | 183.1±29.0 | 102.1±26.9# | (65.3±43.4) | Task*Group=5.3(1,27)* |
| Physiological | |||||||
| Heart rate | 1.8±2.0 | 0.7±1.9 | 2.6±2.3 | 4.6±1.3 | 12.2±2.6 | 5.8±2.7 | All n.s. |
| Mean arterial pressure | 2.5±1.8 | 2.9±1.9 | −0.5±1.8 | 3.9±2.9 | 8.7±1.3 | −0.4±1.5 | Group=5.5(2,30)** (0, 7.5>12.5) |
| Cortisol | 1.4±1.0 | −1.2±1.4 | 2.5±1.2 | 9.5±3.5 | 5.0±2.4 | 4.8±1.0 | All n.s. |
| Pre-task Appraisals (PASA) | |||||||
| Self-efficacy | 4.8±0.2 | 3.9±0.2# | 4.5±0.2 | 3.9±0.2 | 3.4±0.2 | 3.8±0.3 | Group=5.1(2,38)* (0, 12.5>7.5) |
| Threat | 3.2±0.2 | 3.5±0.1 | 2.3±0.3#§ | 3.3±0.2 | 3.3±0.1 | 4.0±0.3 | Task*Group=12.1(2,38)*** |
| Challenge | 3.6±0.1 | 3.4±0.1 | 3.2±0.3 | 3.5±0.1 | 3.6±0.1 | 4.0±0.3 | Task*Group=3.2(2,38)* |
| Post-task Appraisals (PASA VAS) | |||||||
| Stressful | 7.3±2.4 | 18.9±6.0 | 16.5±4.1 | 62.9±7.5 | 44.9±7.2 | 58.9±9.1 | Task*Group=3.9(2,39)* |
| Challenging | 12.3±4.2 | 27.0±7.5 | 34.8±7.5 | 71.4±5.3 | 54.1±7.4 | 70.0±5.4 | Task*Group=4.3(2,39)* |
| Know how to influence | 85.4±6.7 | 67.8±6.9 | 67.9±7.6 | 66.9±8.2 | 43.5±7.5 | 34.6±6.7 | Group=5.9(2,39)** (0>7.5, 12.5) |
| Ability to influence | 84.4±6.8 | 67.3±6.0 | 61.9±7.2 | 56.4±7.8 | 50.0±8.8 | 43.6±9.2 | All n.s. |
| Satisfaction | 81.6±3.8 | 62.5±7.7 | 64.0±6.2 | 36.1±6.8 | 45.7±7.4 | 43.0±10.2 | Task*Group=3.7(2,39)* |
| TSST Performance | |||||||
| # Pauses (speech phase) | 0.7±0.2 | 1.7±0.4 | 2.2±0.6 | Group=3.2(2,41)* (12.5>0) | |||
| % Correct (arithmetic phase) | 88.7±2.7 | 86.3±2.2 | 87.3±3.3 | All n.s. | |||