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Neutralization of HIV-1 Env-pseudotyped viruses (A) Bal.01, (B) JRFL, (C) YU2, and (D) HxBc2, as examples of X4-tropic viruses, by the bifunctional chimera (red), UM15 (black), LJC240−L4 (blue), and a 1:1 mixture of UM15 and LJC240−L4 (green). ND indicates not determined.
