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. Author manuscript; available in PMC: 2019 Jan 28.
Published in final edited form as: J Med Chem. 2018 Jun 1;61(11):5020–5033. doi: 10.1021/acs.jmedchem.8b00477

Figure 6.

Figure 6.

(A) Synergy-assay results between UM15 and LJC240−L4 against HIV-Bal.01. The IC50 values (blue for LJC240−L4 and black for UM15) are the effective inhibitory concentrations of the individual components in the mixture. Chimera 11 (red) was also included in the experiment. (B) Isobologram representation of the UM15−LJC240−L4 combination. The blue line connects the IC50 values of the two inhibitors; the red dot is the effective concentration of the noncovalent mixture (1:30 ratio which achieved 50% inhibition), whereas the green dot is the effective concentration of the covalent chimera, 11.