Fig. 3. Testing PEG-linked vinyl sulfonamides against TS. TS (10 μM) was incubated with a mixture of positive control and negative control ligands (each at 100 μM) and analyzed by intact protein mass spectrometry after 30 minutes. (a) Testing PEG(n = 1) ligands 15a and 15a (b) testing PEG(n = 2) ligands 16a and 16b.
