Table 1.
Relationship between LIPH expression and clinicopathological characteristics in TCGA cohort
| Characteristics | Expression of LIPH, n (%)
|
P-value | |
|---|---|---|---|
| Low (n=252) | High (n=252) | ||
|
| |||
| Age at diagnosis | |||
| Mean ± SD | 48.34±16.20 | 46.17±15.43 | 0.126 |
| <45 years | 110 (43.7) | 119 (47.2) | 0.421 |
| ≥45 years | 142 (56.3) | 133 (52.8) | |
| Gender | 0.547 | ||
| Female | 181 (71.8) | 187 (74.2) | |
| Male | 71 (28.2) | 65 (25.8) | |
| Histological type | <0.001*** | ||
| Classical | 153 (60.7) | 204 (81.0) | |
| Other specified | 99 (39.3) | 48 (19.0) | |
| Tumor size | |||
| Mean ± SD | 2.99±1.76 | 2.81±1.58 | 0.235 |
| ≤2 cm | 85 (35.3) | 86 (36.8) | 0.736 |
| >2 cm | 156 (64.7) | 148 (63.2) | |
| T stage | 0.213 | ||
| T1 | 77 (30.8) | 65 (25.8) | |
| >T1 | 173 (69.2) | 187 (74.2) | |
| Unilateral or bilateral | 0.236 | ||
| Unilateral | 214 (84.9) | 204 (81.0) | |
| Bilateral | 38 (15.1) | 48 (19.0) | |
| Multifocal or unifocal | 0.588 | ||
| Multifocal | 110 (44.5) | 116 (47.0) | |
| Unifocal | 137 (55.5) | 131 (53.0) | |
| Extrathyroidal invasion | <0.001*** | ||
| Yes | 53 (22.0) | 100 (40.8) | |
| No | 188 (78.0) | 145 (59.2) | |
| Lymph-node metastasis | <0.001*** | ||
| Yes | 82 (37.3) | 142 (60.7) | |
| No | 138 (62.7) | 92 (39.3) | |
| Metastasis | 0.252 | ||
| M0 | 130 (94.9) | 150 (98.0) | |
| M1 | 7 (5.1) | 3 (2.0) | |
| AJCC disease stage | 0.023* | ||
| I + II | 180 (71.7) | 156 (62.2) | |
| III + IV | 71 (28.3) | 95 (37.8) | |
Note:
*
P<0.05,
***
P<0.001.
Abbreviations: AJCC, American Joint Committee on Cancer; LIPH, lipase H; TCGA, The Cancer Genome Atlas.