Table 2.
Overall survival stratified by clinical characteristics and univariate Cox proportional hazard analyses for patients with CCAL
| Factor | Category | OS (months), median (IQR) | Univariate | |
|---|---|---|---|---|
| HR (95% CI) | P-value | |||
| Age (years) | <65 | 24.0 (21.0–32.0) | Reference | |
| >65 | 14.0 (11.0–18.0) | 1.44 (1.27–1.63) | <0.01 | |
| Gender | Female | 24.0 (20.0–31.0) | Reference | |
| Male | 14.0 (12.0–18.0) | 1.19 (1.05–1.35) | <0.01 | |
| Race | White | 19.0 (16.0–22.0) | Reference | |
| Black | 13.0 (10.0–24.0) | 1.06 (0.87–1.30) | 0.54 | |
| Others | 20.0 (16.0–28.0) | 0.82 (0.59–1.14) | 0.24 | |
| Pathological differentiation | Well | 39.0 (16.0–73.0) | Reference | |
| Moderate | 46.0 (36.0–63.0) | 0.82 (0.57–1.16) | 0.26 | |
| Poor | 22.0 (18.0–27.0) | 1.19 (0.86–1.67) | 0.29 | |
| Undifferentiated | 22.0 (15.0–43.0) | 0.99 (0.65–1.51) | 0.96 | |
| Summary stage | Localized | 55.0 (46.0–70.0) | Reference | |
| Regional | 28.0 (23.0–33.0) | 1.37 (1.17–1.61) | <0.01 | |
| Distant | 4.0 (3.0–5.0) | 5.96 (5.02–7.07) | <0.01 | |
| Laterality | Left | 20.0 (16.0–26.0) | Reference | |
| Right | 20.0 (17.0–23.0) | 0.99 (0.87–1.12) | 0.90 | |
| Bilateral | 3.0 (1.0–6.0) | 3.98 (2.33–6.79) | <0.01 | |
| Primary site | Main bronchus | 8.0 (2.0–10.0), | Reference | |
| Upper lobe, lung | 25.0 (21.0–31.0) | 0.46 (0.31–0.69) | <0.01 | |
| Middle lobe, lung | 24.0 (17.0–45.0) | 0.50 (0.31–0.80) | <0.01 | |
| Lower lobe, lung | 21.0 (16.0–30.0) | 0.51 (0.34–0.76) | <0.01 | |
| Overlapping | 21.0 (10.0–85.0) | 0.40 (0.21–0.75) | <0.01 | |
| Lymph node metastases | N0 | 44.0 (40.0–51.0) | Reference | |
| N1 | 21.0 (16.0–26.0) | 1.31 (1.06–1.63) | <0.01 | |
| N2 | 9.0 (7.0–11.0) | 2.25 (1.87–2.71) | <0.01 | |
| N3 | 6.0 (4.0–7.0) | 3.56 (2.44–5.21) | <0.01 | |
| Distant metastases | No | 38.0 (33.0–43.0) | Reference | |
| Yes | 4.0 (3.0–5.0) | 5.23 (4.48–6.10) | <0.01 | |
| TNM | I | 63.0 (50.0–76.0) | Reference | |
| II | 30.0 (22.0–45.0) | 1.30 (0.99–1.71) | 0.06 | |
| III | 16.0 (11.0–20.0) | 2.23 (1.86–2.67) | <0.01 | |
| IV | 4.0 (3.0–5.0) | 7.1 (5.95–8.55) | <0.01 | |
| Surgery | No | 5.0 (4.0–6.0) | Reference | |
| Yes | 45.0 (41.0–51.0) | 0.22 (0.19–0.25) | <0.01 | |
| Radiation | No | 27.0 (22.0–33.0) | Reference | |
| Yes | 10.0 (9.0–12.0) | 1.59 (1.39–1.82) | <0.01 | |
| Surgery type | Partial resection | 41.0 (27.0–53.0) | Reference | |
| Lobectomy/bilobectomy | 48.0 (43.0–60.0) | 0.81 (0.65–0.99) | 0.07 | |
| Pneumonectomy | 32.0 (16.0–107.0) | 0.85 (0.57–1.27) | 0.44 | |
| Tumor size (mm) | <39 | 40.0 (33.0–45.0) | Reference | |
| >39 | 16.0 (13.0–19.0) | 1.48 (1.29–1.71) | <0.01 | |
Abbreviations: CCAL, clear cell adenocarcinoma of the lung; OS, overall survival.