Table 3.
Multivariate Cox proportional hazard analyses of clinical characteristics for overall survival rates in patients with CCAL
| Factor | Category | Multivariate | ||
|---|---|---|---|---|
| N | HR (95% CI) | P-value | ||
| Age (years) | <65 | 417 | Reference | |
| >65 | 421 | 1.54 (1.31–1.82) | <0.01 | |
| Gender | Female | 421 | Reference | |
| Male | 417 | 1.05 (0.89–1.22) | 0.59 | |
| Laterality | Left | 355 | Reference | |
| Right | 483 | 1.02 (0.87–1.20) | 0.38 | |
| Bilateral | 0 | – | ||
| Primary site | Main bronchus | 14 | Reference | |
| Upper lobe, lung | 526 | 1.42 (0.79–2.54) | 0.24 | |
| Middle lobe, lung | 48 | 1.97 (0.99–3.87) | 0.06 | |
| Lower lobe, lung | 232 | 1.58 (0.87–2.86) | 0.14 | |
| Overlapping | 18 | 1.35 (0.61–3.00) | 0.46 | |
| Tumor size (mm) | <39.9 | 498 | Reference | |
| >39.9 | 340 | 1.20 (1.02–1.42) | 0.03 | |
| Lymph node metastases | N0 | 510 | Reference | |
| N1 | 107 | 1.34 (1.04–1.73) | 0.03 | |
| N2 | 180 | 1.67 (1.33–2.11) | <0.01 | |
| N3 | 41 | 2.20 (1.49–3.25) | <0.01 | |
| Distant metastases | No | 691 | Reference | |
| Yes | 144 | 2.88 (2.20–3.78) | <0.01 | |
| Surgery | No | 190 | Reference | |
| Yes | 648 | 0.44 (0.33–0.59) | <0.01 | |
| Radiation | No | 608 | Reference | |
| Yes | 230 | 0.97 (0.79–1.20 | 0.81 | |
Abbreviation: CCAL, clear cell adenocarcinoma of the lung.