Table 1.

MiR-145 target molecules and consequences of their targeting in common tumors

Tumor type	Target molecule	Effect	Reference
Thyroid cancer	PI3K/AKT	Differentiation, proliferation, invasion, metastasis	44
Non-small-cell lung cancer	AEG-1/MTDH	Invasion, metastasis	89
	PI3K/AKT, RAS/ERK	Differentiation, proliferation, invasion, metastasis	27
	Oncolytic HSV-1	Sensitivity	64
	c-Myc	Proliferation	80
Lung adenocarcinoma	OCT4	Proliferation, endothelial-mesenchymal transition	90
	FR, NUDT1	Differentiation, proliferation, invasion, metastasis	26
	N-cadherin	Invasion, metastasis	34
Liver cancer	ADAM17	Proliferation	91
	IRS1	Proliferation	83
Pancreatic cancer	MUC13/HER2	Proliferation, invasion	66
	MUC13, ERBB2	Proliferation, invasion, sensitivity	65
	p70S6K1	Sensitivity	14
	SET, RPA1, MCM2, ABCC1, SPTBN1, SPTLC1	Proliferation	62
Colorectal cancer	PPAR-γ/SOX9	Differentiation	23
	mTOR/p70S6K1	Proliferation, angiogenesis	29
	DFF45	Proliferation	82
	FLI1	Invasion, metastasis	88
	YES, STAT1	Proliferation	21
Gastric cancer	IRS-1/β-actin	Proliferation	92
Gut tumors	ERK5/c-Myc, p68/p72/β-catenin	Proliferation	28
Bladder cancer	IGF-IR/PAK1 SENP1	Proliferation, invasion Proliferation, invasion, metastasis	93,94 30
	FSCN1	Proliferation	76
Renal cell carcinoma	MMP-11	Proliferation, invasion	49
	HIF2α/VEGF/MMP9/CCND1	Invasion, metastasis	59
	ADAM17, c-Myc	Proliferation, sensitivity	77,78
Prostate cancer	TNFSF-10	Proliferation	29
	PCGEM1	Proliferation, invasion, metastasis, sensitivity	58
	FSCN1	Proliferation, invasion, metastasis	8
Urothelial cancer	Caspase	Proliferation	79
Breast cancer	MUC1	Invasion, metastasis	81
	JAM-A, fascin	Metastasis	33
	RTKN	Proliferation	81
	ER-alpha	Proliferation	63
Ovarian cancer	MTDH	Proliferation	95
	Cdk6, Sp1, ABCB1, RB1	Sensitivity	66
Osteosarcoma	ROCK1	Proliferation, invasion	87
Chondrosarcoma	SOX9, ETV-5, MMP-2	Metastasis	57
Pleural mesothelioma	OCT4/ZEB1	Proliferation, invasion, sensitivity	20
Glioma	RhoA/ROCK1	Invasion	84
Invasive glioblastoma	srGAP1	Invasion	86