Table 2.

IC₅₀ in mad deletions strains in BY4743 and AD1–9 background

IC₅₀ values were calculated based on best-fitting curve displayed. p values were calculated using a Student's t test with 3 biological replicates. Significant p values (<0.05) are italicized in bold.

Drug	Strain	BY4743		AD1–9
		IC50	p	IC50	p
		μm		μm
5	hoΔ	111.6		78.3
	mad1Δ	140.2	0.009	86.3	0.216
	mad2Δ	138.3	0.015	90	0.286
	mad3Δ	137.3	0.018	88.1	0.18
6	hoΔ	8.6		7.84
	mad1Δ	11.7	0.018	7.32	0.52
	mad2Δ	12.4	0.014	7.02	0.327
	mad3Δ	11.6	0.021	5.86	0.144
7	hoΔ	53.5		43.76
	mad1Δ	80.5	0.013	41.11	0.637
	mad2Δ	73.6	0.031	45.94	0.737
	mad3Δ	80	0.013	39.71	0.426
8	hoΔ	252.8		0.95
	mad1Δ	359.9	0.007	0.59	1
	mad2Δ	345.3	0.02	0.59	0.47
	mad3Δ	326.6	0.014	0.63	0.917
9	hoΔ	12.3		0.6
	mad1Δ	16.5	0.021	8.64	0.909
	mad2Δ	16.4	0.019	7.9	0.533
	mad3Δ	19.9	0.005	7.17	0.176