Figure 1.

Upregulated CD147 expression was associated with aggressive clinicopathologic features and poor prognosis in HNSCC. (A) The relative CD147 mRNA levels of 88 paired tumor and adjacent non‐tumor tissues in HNSCC is shown. ****P < 0.0001, based on Student's t test. (B) The CD147 protein expression levels in 12 paired tumor and adjacent non‐tumor tissues in HNSCC is shown. Tublin was used as a loading control. (C) Immunohistochemistry (IHC) of CD147 expression level on tissue microarrays containing 101 paired HNSCC and 10 normal tissues is shown. Relative negative, weak, moderate and strong PTK7 stain images compared with normal tissues are shown. (D) The probability of overall survival for CD147‐low expression group and CD147‐high expression group of the 101 patients were significantly different (P < 0.05). (E) The probability of disease free survival for CD147‐low expression group and CD147‐high expression group of the 101 patients were significantly different (P < 0.05). The life status of some patients are missing. Therefore, the total patients are not 101