Figure 7.

UPARANT effects on inflammatory markers. (A) Representative blots showing protein levels of iNOS, ICAM‐1, pNF‐kB p65 (Ser²⁷⁶), NF‐kB p65, pCREB (Ser¹³³), CREB and HIF‐1α. β‐actin was used as the loading control. (B‐H) Densitometric analysis showing that UPARANT at 8 mg/kg, but not at 1 mg/kg, reduced up‐regulated levels of iNOS, ICAM‐1, pNF‐kB p65 (Ser²⁷⁶), pCREB (Ser¹³³) and HIF‐1α (*P < 0.05, **P < 0.001 and ***P < 0.001 vs control; ^§ P < 0.001 vs STZ; one‐way ANOVA followed by Newman‐Keuls’ multiple comparison posttest). Data are presented as scatter plots. Each plot represents the mean ± SEM of data from three independent samples