Table 1.
Physiological and renal parameters
| Control | STZ | STZ + UPARANT, 1 mg/kg | STZ + UPARANT, 8 mg/kg | |
|---|---|---|---|---|
| Bodyweight (g) | 373.7 ± 2.7 | 245.2 ± 2.6* | 246.3 ± 4.0* | 248.3 ± 3.0* |
| Kidney weight/Bodyweight (mg/g) | 2.64 ± 0.12 | 4.26 ± 0.09* | 4.13 ± 0.08* | 4.03 ± 0.08* |
| Blood glucose (mg/dL) | 127.2 ± 5.5 | 529.8 ± 18.3* | 539.3 ± 20.3* | 563.5 ± 11.7* |
| Urine output (mL) | 15.6 ± 0.9 | 163.1 ± 7.2* | 158.7 ± 6.2* | 94.4 ± 1.9* , † |
| Urine albumin (mg/24 h) | 0.628 ± 0.013 | 2.088 ± 0.047* | 2.080 ± 0.079* | 1.178 ± 0.039* , † |
| Urine creatinine (mg/24 h) | 13.43 ± 0.25 | 17.40 ± 0.41* | 17.27 ± 0.45* | 13.36 ± 0.26† |
| Albumin to creatinine ratio | 0.041 ± 0.001 | 0.154 ± 0.005* | 0.153 ± 0.003* | 0.066 ± 0.002* , † |
| Plasma creatinine (mg/mL) | 0.430 ± 0.017 | 0.937 ± 0.043* | 0.925 ± 0.042* | 0.653 ± 0.048* , † |
| Creatinine clearance (μL/min/g) | 3.521 ± 0.177 | 7.560 ± 0.290* | 7.366 ± 0.382* | 5.976 ± 0.313* , † |
| Blood urea nitrogen (mmol/L) | 7.71 ± 0.20 | 23.82 ± 0.50* | 23.25 ± 0.41* | 13.85 ± 0.40* , † |
| Systolic blood pressure (mmHg) | 125.4 ± 5.1 | 127.3 ± 1.9 | 130.3 ± 3.4 | 127.4 ± 3.9 |
*P < 0.001 vs control; † P < 0.001 vs STZ (one‐way ANOVA followed by Newman‐Keuls’ multiple comparison posttest).