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. 2018 Oct 28;23(2):852–864. doi: 10.1111/jcmm.13985

Figure 7.

Figure 7

Increased miR‐19a‐3p expression rescued pre‐eclampsia (PE) symptoms in a mouse model. A mouse model of PE was established using sFlt‐1. Among 36 PE mice, 12 mice were randomly selected for mmu‐miR‐agomir treatment as a negative control (PE+NC), 12 for mmu‐miR‐19a‐3p agomir treatment (PE+Agomir), and 12 as a PE control (PE). In addition, another 12 normal pregnant mice were orally treated with saline solution as a control (Nor). (A) miR‐19a‐3p expression in placentas was assessed via RT‐PCR. (B) Protein levels of IL1RAP, caspase‐3, and MMP‐9 in placentas were assessed via western blot assay. (C) Ki67 expression in placentas was assessed via immunohistochemical staining. (D) The blood pressure, (E) urine protein concentrations, and (F) fetal survival number of the mice were recorded. *P < 0.05, **P < 0.01 vs Normal group; # P < 0.05, ## P < 0.01 vs PE group